Antidepressant medication can improve hypertension in elderly patients with depression
Antidepressant medication can improve hypertension in elderly patients with depression
复制标题
DOI：
10.1016/j.jocn.2015.03.067
复制
发表时间：
2015-12-01
影响因子：
2
通讯作者：
Liu, Huizhen
中科院分区：
文献类型：
--
作者：
Fu, Wenjing;Ma, Lina;Liu, Huizhen
探讨抗抑郁治疗对老年高血压患者血压及生活质量的影响。高血压患者的抑郁发生率高于正常人群。据报道，抑郁症状导致高血压控制较差，导致并发症的发展。我们进行了一项随机、平行组研究。选择2008年8月至2011年3月期间收治的70例老年高血压患者，根据其降压治疗分为两组，对照组（西酞普兰5mg/d; n = 35）和治疗组（西酞普兰5mg/d;西酞普兰20mg/d; n = 35）。我们比较了24小时、白天和夜间收缩压和舒张压的测量值，以及生活质量，使用汉密尔顿抑郁量表和36项简明生活质量问卷（SF-36）进行评估。两组均随访3个月。治疗3个月后，治疗组各项血压水平均显著低于对照组。其他评分（SF-36生活质量量表的身体功能亚类除外）显著较高。我们的研究提示临床医生应注意老年高血压患者的抑郁症状，并应考虑对这些患者进行抗抑郁治疗。(C)2015爱思唯尔有限公司版权所有。
We explored the influence of antidepressant therapy on blood pressure and quality of life in elderly patients with hypertension. Depression occurs at a higher rate in patients with hypertension than in the normal population. It has been reported that depressive symptoms lead to poorer hypertension control, resulting in the development of complications. We conducted a randomized, parallel group study. A total of 70 elderly patients with hypertension in the period of August 2008 to March 2011 were divided into two,groups based on their antihypertensive therapy, a control group (amlodipine, 5 mg daily; n = 35) and a therapy group (amlodipine, 5 mg daily; citalopram, 20 mg daily; n = 35). We compared 24 hour, daytime, and nighttime measurements of systolic and diastolic blood pressure, in addition to quality of life, assessed using the Hamilton rating scale for depression, and a 36 item Short Form quality of life questionnaire (SF-36). Both groups were followed for 3 months. At the end of 3 months, all blood pressure levels were significantly lower in the therapy group than in the control group. The other scores (with the exception of the physical function subcategory of the SF-36 quality of life scale) were significantly higher. Our study indicates that clinicians should be aware of depressive symptoms in elderly patients with hypertension, and should consider antidepressant therapy in these patients. (C) 2015 Elsevier Ltd. All rights reserved.