Future directions of studies for recurrent miscarriage associated with immune etiologies
Future directions of studies for recurrent miscarriage associated with immune etiologies
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DOI：
10.1016/j.jri.2011.03.003
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发表时间：
2011-06-01
影响因子：
3.4
通讯作者：
Shima, Tomoko
中科院分区：
文献类型：
--
作者：
Saito, Shigeru;Nakashima, Akitoshi;Shima, Tomoko
复发性流产（RPL）很大一部分与免疫病因相关。基蜕膜和壁蜕膜之间的免疫环境不同，胎儿染色体正常的复发性流产病例和胎儿染色体异常的病例之间的免疫环境也不同。近期数据显示，晚期流产的免疫系统与早期流产的完全不同。如果免疫活性细胞可导致复发性流产，那么免疫环境可能是一个致病因素，尤其是在早期流产以及/或者在基蜕膜和/或者在胚胎正常的复发性流产病例中。仔细检查胎儿染色体正常的复发性流产病例早期流产时基蜕膜的免疫系统可能会揭示有用的信息。（C）2011爱思唯尔爱尔兰有限公司。保留所有权利。
A significant proportion of recurrent pregnancy loss (RPL) is associated with immune etiologies. The immunological environment is different between decidua basalis and decidua parietalis, and also different between RPL cases with normal fetal chromosomes and those with abnormal fetal chromosomes. Recent data show that the immune system in a late-stage abortion is completely different from that in an early-stage abortion. If immunocompetent cells can cause RPL, the immunological environment may be a causative factor, especially in an early-stage abortion, and/or at decidua basalis and/or in the cases of RPL with a normal embryo. Careful examination of the immune system at the decidua basalis in an early-stage abortion in RPL cases with normal fetal chromosome may reveal useful information. (C) 2011 Elsevier Ireland Ltd. All rights reserved.