Monitoring tissue temperature during photothermal therapy for cancer.
Monitoring tissue temperature during photothermal therapy for cancer.
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DOI：
10.1097/jbr.0000000000000050
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发表时间：
2019-12
期刊：
影响因子：
--
通讯作者：
Chen WR
中科院分区：
文献类型：
--
作者：
West CL;Doughty ACV;Liu K;Chen WR
光疗法为传统的癌症疗法提供了有希望的替代方案。光疗法主要依靠通过光热、光化学或光力学相互作用来操纵靶组织。光疗与免疫疗法相结合的好处是引起全身免疫反应。具体来说，光热疗法（PTT）已被证明可以诱导癌细胞凋亡和坏死，释放肿瘤相关的抗原肽，同时保留健康的宿主细胞，通过在靶组织中升高温度。然而，为了达到预期的PTT治疗效果，必须监测和控制组织温度，以尽量减少对正常组织的不利热效应，并避免破坏肿瘤特异性抗原。监测PTT的技术已经从酶联免疫吸附测定、western blot分析和流式细胞术等治疗后定量方法发展到能够实时监测的现代方法，如磁共振测温、计算机断层扫描和光声成像。监测方法的选择在很大程度上是基于光传递到目标组织的类型。温度测量的间隙方法，如热电偶和光纤传感器，能够监测局部肿瘤环境的温度。然而，如果光疗法本身是间隙性的，这些方法可能具有挑战性。越来越多的非侵入性治疗需要非侵入性监测，这可以通过磁共振测温、计算机断层扫描和光声成像技术来实现。本文综述的目的是介绍PTT过程中组织温度监测的可行方法。不同技术的描述和测量实例可以帮助研究者和实践者使用治疗性PTT。
Phototherapies offer promising alternatives to traditional cancer therapies. Phototherapies mainly rely on manipulation of target tissue through photothermal, photochemical, or photomechanical interactions. Combining phototherapy with immunotherapy has the benefit of eliciting a systemic immune response. Specifically, photothermal therapy (PTT) has been shown to induce apoptosis and necrosis in cancer cells, releasing tumor associated antigenic peptides while sparing healthy host cells, through temperature increase in targeted tissue. However, the tissue temperature must be monitored and controlled to minimize adverse thermal effects on normal tissue and to avoid the destruction of tumor-specific antigens, in order to achieve the desired therapeutic effects of PTT. Techniques for monitoring PTT have evolved from post-treatment quantification methods like enzyme linked immunosorbent assay, western blot analysis, and flow cytometry to modern methods capable of real-time monitoring, such as magnetic resonance thermometry, computed tomography, and photoacoustic imaging. Monitoring methods are largely chosen based on the type of light delivery to the target tissue. Interstitial methods of thermometry, such as thermocouples and fiber-optic sensors, are able to monitor temperature of the local tumor environment. However, these methods can be challenging if the phototherapy itself is interstitially administered. Increasingly, non-invasive therapies call for non-invasive monitoring, which can be achieved through magnetic resonance thermometry, computed tomography, and photoacoustic imaging techniques. The purpose of this review is to introduce the feasible methods used to monitor tissue temperature during PTT. The descriptions of different techniques and the measurement examples can help the researchers and practitioners when using therapeutic PTT.