Microbial transformation of 10-deacetylbaccatin III (10-DAB) by Curvularia lunata and Trametes hirsuta
Microbial transformation of 10-deacetylbaccatin III (10-DAB) by Curvularia lunata and Trametes hirsuta
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DOI：
10.1016/j.molcatb.2006.07.006
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发表时间：
2006-11-02
影响因子：
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通讯作者：
Fontana, Gabriele
中科院分区：
文献类型：
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作者：
Arnone, Alberto;Bava, Adriana;Fontana, Gabriele
研究了 10-脱乙酰浆果赤霉素 III (10-DAB) (1a) 和 13-DeBAC (4b) 的微生物转化。毛栓菌诱导 10-DAB 进行 13 氧化，以高产率产生 (4a)，而与新月弯孢菌一起孵育则导致分离出 7-epi-10-DAB (2) 和 7-epi-10-oxo-10-DAB (3)。 13-DeBAC (4b) 被链格孢 (Alternaria alternata) 生物转化为化合物 (4a) 和 (4c)。 (c) 2006 Elsevier B.V. 保留所有权利。
The microbial transformation of 10-deacetylbaccatin III (10-DAB) (1a) and 13-DeBAC (4b) was investigated. Trametes hirsuta induced 13-oxidation of 10-DAB to give (4a) in high yield, whereas incubation with Curvularia lunata resulted in the isolation of the 7-epi-10-DAB (2) and the 7-epi-10-oxo-10-DAB (3). 13-DeBAC (4b) was biotransformed into compounds (4a) and (4c) by Alternaria alternata. (c) 2006 Elsevier B.V. All rights reserved.