Effect of equipment layout on bioaerosol temporal-spatial distribution and deposition in one BSL-3 laboratory
Effect of equipment layout on bioaerosol temporal-spatial distribution and deposition in one BSL-3 laboratory
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BSL-3实验室设备布局对生物气溶胶时空分布和沉积的影响
DOI：
10.1016/j.buildenv.2020.107149
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发表时间：
2020-08-15
影响因子：
7.4
通讯作者：
Li, Na
中科院分区：
文献类型：
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作者：
Liu, Zhijian;Zhuang, Wenbin;Li, Na
合理的设备布局对于创造健康安全的环境至关重要，特别是在具有高潜在感染风险因素的三级生物安全实验室。2019年以来，新冠肺炎这一新兴传染病席卷全球，造成严重损失。生物安全实验室是检测高危病毒的强制性场所，因此迫切需要进行相关研究，以防止操作员在实验室获得进一步感染。本研究利用相关实验设备，调查了生物安全实验室内障碍物对工作人员暴露感染的影响。数值模拟结果与实测结果吻合较好。结果表明，虽然设备布置不影响生物气溶胶的去除时间，但与理想情况相比，实际实验室中近17%的污染物颗粒无法有效排放。这些颗粒在漩涡的影响下徘徊在较低的空间，这会增加操作人员的呼吸风险。此外，实验结束后，大部分生物气溶胶颗粒会被设备和地板捕获，单位面积的沉积速率分别为0.45%/m(2)和0.8%/m(2)。结果表明，虽然设备布置可以减少地板上的污染，但消毒仍然是一个重要的环节，特别是对设备表面的消毒。同时，结果还表明，在BSL-3实验室运行时，作用应轻而慢，以避免生物气溶胶颗粒对设备表面和地板的二次悬浮污染。
Reasonable equipment layout is essential for creating a healthy and safe environment, especially in a three-level biosafety laboratory with high potential risk factors of infection. Since 2019, COVID-19, an emerging infection has swept the world and caused severe losses. Biosafety laboratories are mandatory sites for detecting high-risk viruses, so related research is urgently needed to prevent further laboratory-acquired infections of operators. This study investigated the effects of obstacles on exposure infection of staff in a biosafety laboratory with related experimental equipment. The numerical simulation results are highly verified by the measured results. The results indicate that although the equipment layout does not affect the bioaerosol removal time, nearly 17% of the pollutant particles in the actual laboratory cannot be discharged effectively compared with the ideal situation. These particles lingered in the lower space under the influence of vortex, which would increase the respiratory risk of operators. In addition, after the experiment a large part of bioaerosol particles would be captured by equipment and floor, and the deposition rate per unit area is 0.45%/m(2) and 0.8%/m(2), respectively. Although the results show that the equipment layout could reduce the pollution on the floor, the disinfection is still an important link, especially on the surfaces of equipment. Meanwhile, the result also indicates that the action should be light and slow when operating in BSL-3 laboratory, so as to avoid the secondary suspension pollution of bioaerosol particles on the equipment surface and floor.