STEM CELL THERAPIES, GENE-BASED THERAPIES, OPTOGENETICS, AND RETINAL PROSTHETICS: Current State and Implications for the Future.
STEM CELL THERAPIES, GENE-BASED THERAPIES, OPTOGENETICS, AND RETINAL PROSTHETICS: Current State and Implications for the Future.
复制标题
干细胞疗法、基于基因的疗法、光遗传学和视网膜修复术：现状和对未来的影响。
DOI：
10.1097/iae.0000000000002449
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发表时间：
2019
期刊：
影响因子：
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通讯作者：
Williams,GeorgeA
中科院分区：
文献类型：
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作者：
Wood,EdwardH;Tang,PeterH;DelaHuerta,Irina;Korot,Edward;Muscat,Stephanie;Palanker,DanielA;Williams,GeorgeA
目的：回顾和讨论视网膜领域有前途的生物技术和生物医学产品的当前创新和未来影响。我们专注于已经出现在临床产品或准备这样做的疗法。方法：对干细胞治疗、基因治疗、光遗传治疗、视网膜修复装置等方面的文献进行综述和评述。结果：本文讨论的技术是视网膜领域最新的生物技术和生物医学发展。视网膜假体设备和基于基因的疗法都有fda批准的眼科产品，还有许多其他产品（包括光遗传学）正在筹备中。干细胞疗法通过新的再生机制提供个性化治疗，但涉及复杂的伦理和报销挑战。结论：干细胞疗法、基因疗法、光遗传学和视网膜假体装置代表了生物技术和生物医学进步的新时代。这些带来了新的伦理、监管、医疗服务和报销方面的挑战。通过积极地解决这些问题，我们可以以安全、高效和基于价值的方式加速向患者提供护理。
Purpose:To review and discuss current innovations and future implications of promising biotechnology and biomedical offerings in the field of retina. We focus on therapies that have already emerged as clinical offerings or are poised to do so.Methods:Literature review and commentary focusing on stem cell therapies, gene-based therapies, optogenetic therapies, and retinal prosthetic devices.Results:The technologies discussed herein are some of the more recent promising biotechnology and biomedical developments within the field of retina. Retinal prosthetic devices and gene-based therapies both have an FDA-approved product for ophthalmology, and many other offerings (including optogenetics) are in the pipeline. Stem cell therapies offer personalized medicine through novel regenerative mechanisms but entail complex ethical and reimbursement challenges.Conclusion:Stem cell therapies, gene-based therapies, optogenetics, and retinal prosthetic devices represent a new era of biotechnological and biomedical progress. These bring new ethical, regulatory, care delivery, and reimbursement challenges. By addressing these issues proactively, we may accelerate delivery of care to patients in a safe, efficient, and value-based manner.