Genome sequence survey identifies unique sequences and key virulence genes with unusual rates of amino acid substitution in bovine Staphylococcus aureus
Genome sequence survey identifies unique sequences and key virulence genes with unusual rates of amino acid substitution in bovine Staphylococcus aureus
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DOI：
10.1128/iai.70.7.3978-3981.2002
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发表时间：
2002-07-01
影响因子：
3.1
通讯作者：
Kapur, V
中科院分区：
文献类型：
--
作者：
Herron, LL;Chakravarty, R;Kapur, V
金黄色葡萄球菌是牛和其它反刍动物物种中乳腺炎的主要原因。在这里，我们提出了牛乳腺炎相关的克隆，RF122，和最近测序的人类相关的克隆，Mu50和N315，金黄色葡萄球菌之间的比较基因组分析的结果。鸟枪测序法对10%的RF122基因组进行了调查，发现了许多独特的序列和非同义替换率升高的序列。总之，这些分析表明，牛乳腺炎相关的和人的S。金黄色葡萄球菌，并提供了一个框架，在这个主要的人类和动物病原体的宿主特异性相关的特定因素的鉴定。
Staphylococcus aureus is a major cause of mastitis in bovine and other ruminant species. We here present the results of a comparative genomic analysis between a bovine mastitis-associated clone, RF122, and the recently sequenced human-associated clones, Mu50 and N315, of Staphylococcus aureus. A shotgun sequence survey of similar to10% of the RF122 genome identified numerous unique sequences and those with elevated rates of nonsynonymous substitution. Taken together, these analyses show that there are notable differences in the genomes of bovine mastitis-associated and human clones of S. aureus and provide a framework for the identification of specific factors associated with host specificity in this major human and animal pathogen.