The value of quantitative EEG in differential diagnosis of Alzheimer's disease and subcortical vascular dementia
The value of quantitative EEG in differential diagnosis of Alzheimer's disease and subcortical vascular dementia
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DOI：
10.1016/j.jns.2009.02.332
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发表时间：
2009-08-15
影响因子：
4.4
通讯作者：
Kowalski, J.
中科院分区：
文献类型：
--
作者：
Gawel, M.;Zalewska, E.;Kowalski, J.
目的：目的：探讨定量脑电图（QEEG）对AD和SVD的鉴别诊断价值，以及AD与EEG异常的相关性（平均年龄：73.6岁，男性51%），31例SVD患者（平均年龄：75.2岁，男性43%）和对照组14例健康受试者（平均年龄：69.5岁，男性43%）。这些患者被分为轻度、中度和显著痴呆亚组。根据慢波的存在情况，使用八度量表对EEG结果进行分类，然后通过计算α/慢波功率比和所有和一些选定的derivations.Results的平均频率进行定量分析：发现AD和SVD的视觉EEG和QEEG之间存在显著差异。结论：视觉EEG和QEEG可作为AD和SVD的鉴别诊断手段，但QEEG的某些参数对AD和SVD的鉴别诊断有一定的参考价值。(C)2009爱思唯尔有限公司版权所有。
Objective: To investigate whether quantitative EEG may be useful in differential diagnosis of AD and SVD and to determine the correlation between dementia and abnormalities in EEG.Materials and methods: The group under study was consisted of 62 patients with AD (mean age: 73.6 yrs; M 51%), 31 with SVD (mean age: 75.2 yrs, M 43%) and a control group of 14 healthy subjects (mean age: 69.5 yrs, M 43%). The patients were divided into subgroups of those with mild, moderate and marked dementia. EEG findings were classified using eight-degree scale according to the presence of slow waves, and then quantitative analysis was carried out by calculating the alpha/slow wave power ratios and the mean frequencies in all and some selected derivations.Results: A significant difference between visual EEGs and QEEGs in AD and SVD was found. Only QEEG parameters differed in AD and SVD subgroups with the same degree of cognitive impairment: the mean wave frequencies of waves in temporal derivations in subgroups with mild and moderate dementia and alphal delta waves power ratio in subgroups with moderate dementia.Conclusions: Visual EEGs and QEEGs could be used in addition to the differential diagnosis between AD and SVD, but only selected parameters of QEEG could be useful in differentiating between AD and SVD subgroups with the same degree of dementia. (C) 2009 Elsevier B.V. All rights reserved.