Prevalence and morbidity of primary immunodeficiency diseases, United States 2001-2007.
Prevalence and morbidity of primary immunodeficiency diseases, United States 2001-2007.
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原发性免疫缺陷疾病的患病率和发病率，2001 - 2007年美国。
DOI：
10.1007/s10875-014-0102-8
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发表时间：
2014-11
影响因子：
9.1
通讯作者：
Bowen S
中科院分区：
文献类型：
--
作者：
Kobrynski L;Powell RW;Bowen S
很少有研究估计原发性免疫缺陷疾病 (PIDD) 的人群患病率和发病率。我们使用行政医疗保健数据库来估计 2001 年至 2007 年美国 PIDD 诊断的患病率。MarketScan 数据库汇编了商业健康保险计划和医疗补助的索赔，记录了门诊和住院的个人诊断。我们使用相关的 ICD-9 代码（279.0、279.1、279.2、279.8、279.9、288.1 和 288.2）进行横断面调查来估计 PIDD 的患病率。诊断为继发性免疫缺陷的人被排除在分析之外。 2001 年至 2007 年间，私人参保人员中 PIDD 诊断患病率从每 10 万人中 38.9 人增加到 50.5 人，公共参保人中从每 10 万人中 29.1 人增加到 41.1 人。 B 细胞缺陷占主导地位。白人的患病率是黑人或西班牙裔的两倍多。在这个大型数据库中，我们发现诊断出的 PIDD 患病率比之前登记处报告的患病率更高。认识的提高可能导致了患病率的增加。
Few studies have estimated population prevalence and morbidity of primary immunodeficiency diseases (PIDD). We used administrative healthcare databases to estimate the prevalence of PIDD diagnoses in the United States from 2001 to 2007. MarketScan databases compile claims from commercial health insurance plans and Medicaid, recording individual diagnoses for outpatient encounters and hospital stays. We used a cross sectional survey to estimate prevalence of PIDD using related ICD-9 codes (279.0, 279.1, 279.2, 279.8, 279.9, 288.1 and 288.2). Persons with secondary immunodeficiency diagnoses were excluded from analysis. Between 2001 and 2007, prevalence of any PIDD diagnosis increased from 38.9 to 50.5 per 100,000 among privately insured and from 29.1 to 41.1 per 100,000 among publicly insured persons. B cell defects predominated. Prevalence was more than twice as high among Whites as among Blacks or Hispanics. In this large database, we found a higher prevalence of diagnosed PIDD than has been reported previously from registries. Increased awareness may have contributed to the increasing prevalence.