Severe coronary artery spasm can be associated with hyperthyroidism
Severe coronary artery spasm can be associated with hyperthyroidism
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DOI：
10.1097/00019501-200505000-00001
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发表时间：
2005-05-01
影响因子：
1.8
通讯作者：
Park, JE
中科院分区：
文献类型：
--
作者：
Choi, YH;Chung, JH;Park, JE
背景 冠状动脉痉挛在韩国并不罕见。大多数冠状动脉痉挛患者在冠状动脉造影中表现为局灶性痉挛。然而，这种疾病的原因尚不清楚。有一些与甲状腺功能亢进相关的冠状动脉痉挛的轶事病例报告，但还没有关于大量此类患者的报告。在5年零8个月的时间里，我们经历了8例与甲状腺功能亢进相关的弥漫性或严重型冠状动脉痉挛的患者。方法我们调查了通过冠状动脉造影或冠状动脉内注射乙酰胆碱或麦角新碱激发诊断的冠状动脉痉挛患者的特征。对8例甲亢合并冠状动脉痉挛患者的人口学资料、冠状动脉造影结果、甲状腺功能检查结果以及随访临床资料进行分析。结果8例患者均患有Graves病。六名患者在冠状动脉造影过程中出现冠状动脉血管收缩，但未注射麦角新碱。在三名患者中，左冠状动脉主干发生痉挛。这八名患者中，有五名是女性，并且所有这些女性患者都是
Background Coronary artery spasm is not infrequently seen in Korea. Most of the patients with coronary spasm show a focal spasm in coronary angiography. However, the cause of the disease is not well known. There have been a few anecdotal case reports of coronary artery spasm associated with hyperthyroidism, but there has not been a report concerning a large series of such patients. Over a period of 5 years and 8 months, we experienced eight patients having the diffuse or severe type of coronary artery spasm in association with hyperthyroidism.Methods We investigated the characteristics of the patients with coronary artery spasm, which was diagnosed by coronary angiography or by provocation with an intracoronary injection of acetylcholine or ergonovine. The demographic data, coronary angiographic findings, thyroid function test results, and the follow-up clinical data of the eight patients having coronary artery spasm associated with hyperthyroidism were analyzed.Results All eight patients had Graves' disease. In six patients, the coronary arterial vasoconstriction developed during the coronary angiography without an injection of ergonovine. In three patients, the left main stem coronary artery was involved in the spasm. Among these eight patients, five were female, and all of these female patients were