Computed tomographic measurements of airway dimensions and emphysema in smokers -: Correlation with lung function
Computed tomographic measurements of airway dimensions and emphysema in smokers -: Correlation with lung function
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DOI：
10.1164/ajrccm.162.3.9907120
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发表时间：
2000-09-01
影响因子：
24.7
通讯作者：
Mishima, M
中科院分区：
文献类型：
--
作者：
Nakano, Y;Muro, S;Mishima, M
慢性阻塞性肺疾病（COPD）的特征是存在由肺气肿或气道狭窄或两者兼而有之引起的气流阻塞。计算机断层扫描 (CT) 上的低衰减区域 (LAA) 已被证明代表宏观或微观肺气肿，或两者兼而有之。然而，CT 尚未用于量化有或没有气流阻塞的吸烟者的气道异常。在这项研究中，我们使用 CT 评估 114 名吸烟者的肺气肿和气道壁增厚。 CT 测量显示 FEV1（% 预测值）下降与气道壁面积增加和肺气肿增加相关。尽管气道壁增厚和肺气肿（LAA）都与肺功能测量相关，但逐步多元回归分析表明，气道和肺气肿测量的结合改善了对肺功能测试异常的估计。我们的结论是，气道尺寸和肺气肿的 CT 测量在评估吸烟者的肺部方面都是有用且互补的。
Chronic obstructive pulmonary disease (COPD) is characterized by the presence of airflow obstruction caused by emphysema or airway narrowing, or both. Low attenuation areas (LAA) on computed tomography (CT) have been shown to represent macroscopic or microscopic emphysema, or both. However CT has not been used to quantify the airway abnormalities in smokers with or without airflow obstruction. In this study, we used CT to evaluate both emphysema and airway wall thickening in 114 smokers. The CT measurements revealed that a decreased FEV1 (%predicted) is associated with an increase of airway wall area and an increase of emphysema. Although both airway wall thickening and emphysema (LAA) correlated with measurements of lung function, stepwise multiple regression analysis showed that the combination of airway and emphysema measurements improved the estimate of pulmonary function test abnormalities. We conclude that both CT measurements of airway dimensions and emphysema are useful and complementary in the evaluation of the lung of smokers.