Artesunate, a potential drug for treatment of Babesia infection
Artesunate, a potential drug for treatment of Babesia infection
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DOI：
10.1016/j.parint.2010.06.004
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发表时间：
2010-09-01
影响因子：
1.9
通讯作者：
Xuan, Xuenan
中科院分区：
文献类型：
--
作者：
Goo, Youn-Kyoung;Terkawi, M. Alaa;Xuan, Xuenan
青蒿琥酯是一种水溶性青蒿素衍生物，研究了青蒿琥酯对包括牛巴贝虫、吉氏巴贝虫和田鼠巴贝虫在内的巴贝虫的作用。B的培养物。bovis和B. gibsoni用0.26、2.6、26和260 μ M青蒿琥酯处理，显示出在B处理后第3天，在等于和大于2.6 μ M青蒿琥酯的浓度下对寄生虫生长的抑制。gibsoni和B.以剂量依赖的方式。与体外实验一致，青蒿琥酯对感染B的小鼠有效。感染后8-10天，剂量等于或大于10 mg/kg体重的田鼠。总之，这些结果表明青蒿琥酯可能是一种潜在的抗巴氏杆菌感染的药物。(C)2010爱思唯尔爱尔兰有限公司版权所有。
The effects of artesunate, a water-soluble artemisinin derivative, against Babesia species, including Babesia bovis, Babesia gibsoni and Babesia microti were studied. Cultures of B. bovis and B. gibsoni were treated with 0.26, 2.6, 26 and 260 mu M artesunate, showing inhibition of parasite growth at concentrations equal to and greater than 2.6 mu M artesunate by days 3 post-treatment for B. gibsoni and B. bovis in a dose-dependent manner. Consistent with in vitro experiments, artesunate was effective in the treatment of mice infected with B. microti at doses equal to and greater than 10 mg/kg of body weight on days 8-10 post-infection. Taken together, these results suggest that artesunate could be a potential drug against Babesia infection. (C) 2010 Elsevier Ireland Ltd. All rights reserved.