A tool for functional brain imaging with lifespan compliance
A tool for functional brain imaging with lifespan compliance
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DOI：
10.1038/s41467-019-12486-x
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发表时间：
2019-11-05
影响因子：
16.6
通讯作者：
Brookes, Matthew J.
中科院分区：
文献类型：
--
作者：
Hill, Ryan M.;Boto, Elena;Brookes, Matthew J.
随着人类认知的基础奠定，人类大脑在生命的最初几十年会经历显着的功能和结构变化。然而，非侵入性成像技术来调查整个神经发育过程中的脑功能是有限的，由于头部大小随着年龄的增长和大量的头部运动在年轻的参与者。探测大脑功能的实验设计也受到典型的大脑成像系统施加的非自然环境的限制。然而，量子技术的发展允许制造新一代可穿戴脑磁图（MEG）技术，该技术有可能彻底改变大脑活动的电生理测量。在这里，我们展示了一个符合寿命要求的MEG系统，显示了幼儿，幼儿，青少年和成人的高保真数据记录。我们展示了这个系统如何支持涉及自然主义学习的新型实验范式。这项工作揭示了功能成像的新方法，为健康和疾病中的神经发育研究提供了一个强大的平台。
The human brain undergoes significant functional and structural changes in the first decades of life, as the foundations for human cognition are laid down. However, non-invasive imaging techniques to investigate brain function throughout neurodevelopment are limited due to growth in head-size with age and substantial head movement in young participants. Experimental designs to probe brain function are also limited by the unnatural environment typical brain imaging systems impose. However, developments in quantum technology allowed fabrication of a new generation of wearable magnetoencephalography (MEG) technology with the potential to revolutionise electrophysiological measures of brain activity. Here we demonstrate a lifespan-compliant MEG system, showing recordings of high fidelity data in toddlers, young children, teenagers and adults. We show how this system can support new types of experimental paradigm involving naturalistic learning. This work reveals a new approach to functional imaging, providing a robust platform for investigation of neurodevelopment in health and disease.