Cathepsin K(+) Non-Osteoclast Cells in the Skeletal System: Function, Models, Identity, and Therapeutic Implications.
Cathepsin K(+) Non-Osteoclast Cells in the Skeletal System: Function, Models, Identity, and Therapeutic Implications.
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骨骼系统中的组织蛋白酶 K 非破骨细胞：功能、模型、身份和治疗意义
DOI：
10.3389/fcell.2022.818462
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发表时间：
2022
影响因子：
5.5
通讯作者：
中科院分区：
文献类型：
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作者：
组织蛋白酶K（Ctsk）是最初在分化的破骨细胞中鉴定的木瓜蛋白酶超家族的半胱氨酸蛋白酶;其在降解骨基质中起关键作用。然而，随后的体内和体外研究的基础上的动物模型阐明了新的亚群Ctsk表达细胞，其显示标志物和间充质干/祖细胞的属性。本文综述了Ctsk+细胞的功能、特性和作用及其在相关临床前骨疾病模型中的治疗意义。它还总结了可用于研究Ctsk+细胞及其后代的体内模型。需要进一步研究转基因模型中Ctsk+细胞的详细特性和机制，以指导未来多种疾病的潜在治疗靶点。
Cathepsin K (Ctsk) is a cysteine protease of the papain superfamily initially identified in differentiated osteoclasts; it plays a critical role in degrading the bone matrix. However, subsequent in vivo and in vitro studies based on animal models elucidate novel subpopulations of Ctsk-expressing cells, which display markers and properties of mesenchymal stem/progenitor cells. This review introduces the function, identity, and role of Ctsk+ cells and their therapeutic implications in related preclinical osseous disorder models. It also summarizes the available in vivo models for studying Ctsk+ cells and their progeny. Further investigations of detailed properties and mechanisms of Ctsk+ cells in transgenic models are required to guide potential therapeutic targets in multiple diseases in the future.