Catalytic asymmetric synthesis of 3,3-disubstituted oxindoles: diazooxindole joins the field
Catalytic asymmetric synthesis of 3,3-disubstituted oxindoles: diazooxindole joins the field
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3,3-二取代羟吲哚的催化不对称合成：重氮杂吲哚加入该领域
DOI：
10.1016/j.tetlet.2014.01.084
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发表时间：
2014-04-16
影响因子：
1.8
通讯作者：
Zhou, Jian
中科院分区：
文献类型：
--
作者：
Cao, Zhong-Yan;Wang, Yu-Hui;Zhou, Jian
3，3-二取代羟吲哚类化合物是天然产物和药物中一类重要的骨架化合物，其催化不对称合成是目前研究的热点。最近，重氮羟吲哚的催化不对称官能化作为一种潜在的通用和灵活的策略出现在2013年，有几个值得注意的例子。本文对重氮羟吲哚类化合物的合成应用进行了综述和讨论，有助于读者了解这类给体/受体环重氮试剂的特殊性质，并有助于开发新的催化不对称反应。(C)2014爱思唯尔有限公司版权所有。
The catalytic asymmetric synthesis of 3,3-disubstituted oxindoles, a big family of privileged scaffolds in natural products and drugs, is of current interest. Recently, the catalytic asymmetric functionalization of diazooxindoles emerges as a potentially general and flexible strategy for this purpose, with several notable examples coming out in 2013. In this digest, synthetic applications of diazooxindoles have been summarized and discussed, which might be helpful for readers to understand the special properties of this type of donor/acceptor cyclic diazo reagent and to develop new catalytic asymmetric reactions. (C) 2014 Elsevier Ltd. All rights reserved.