Plateletcrit and red cell-distribution width are independent predictors of the slow coronary flow phenomenon
Plateletcrit and red cell-distribution width are independent predictors of the slow coronary flow phenomenon
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DOI：
10.1016/j.jjcc.2013.07.010
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发表时间：
2014-01-01
影响因子：
2.5
通讯作者：
Haznedaroglu, Ibrahim Celal
中科院分区：
文献类型：
--
作者：
Akpinar, Ibrahim;Sayin, Muhammet Rasit;Haznedaroglu, Ibrahim Celal
背景和目的：内皮功能障碍可能在慢速冠状动脉流（SCF）现象的发病机理中起作用。对于这种情况，尚未对血液细胞成分进行详细检查。我们研究了SCF与全血细胞计数之间的关系。方法：回顾性评估了2006年1月至2012年12月之间接受冠状动脉血管造影的17,315例患者的记录。根据人口统计数据，全血细胞计数和生化参数，将共有146例SCF患者与148例患有正常冠状动脉的患者进行了比较。抗分辨率：SCF患者的以下参数明显高于正常冠状动脉的患者：吸烟者（36.3％vs. 25％，P = 0.036），体重指数（26.69 +/- 2.84 vs. 26.07 +/- 3.15，p = 0.049），白细胞（WBC）（7.52 +/- 1.43 x 10（3）mm（-3）vs. 7.01 +/- 1.42 x 10（3）mm（-3）， p = 0.002），红细胞分布宽度（RDW）（13.68 +/- 1.42％vs. 13.15 +/- 1.13％，p <0.001），血小板（250.29 +/- 50.96 x 10（3）毫米（-3）vs. 226.10 +/- 38.02 x 10（3）mm（-3），p <0.001），血小板（pct）（pct）（0.214 +/- 0.40 ％vs. 0.184 +/- 0.29％，p <0.001），平均血小板体积（8.63 +/- 1.10 fl vs. 8.22 +/- 0.83 fl，p <0.001），血小板分布宽度（PDW）（16.58 +/- 0.76％vs. 16.45 +/- 0.57％，p = 0.028）和中性粒细胞（4.44 +/- 1.25 x 10（ 3）mm（-3）vs. 4.12 +/- 1.24 x 10（3）mm（-3），p = 0.029）。阳性PCT值[优势比（OR），4.165; 95％置信区间（CI），2.493-6.959; P <0.001）和RDW（OR，1.304; 95％Cl，1.034-1.645; P = 0.025）是SCF的独立预测指标。结论：尽管在正常范围内，SCF患者的WBC和中性粒细胞的数量增加了SCF可能是亚临床炎症状况。此外，SCF患者的RDW和PDW增加可能会导致细胞可变形性受损引起的微血管血流阻力。 PCT提供了有关总血小板质量的可靠数据，并且可能是SCF的有用预测指标。 （c）2013年日本心脏病学院。由Elsevier Ltd.出版。保留所有权利。
Background and purpose: Endothelial dysfunction may play a role in the pathogenesis of the slow coronary flow (SCF) phenomenon. A detailed examination of blood cellular components has not been performed for this condition. We investigated the relationship between SCF and whole blood cell counts.Method: Records of 17,315 patients who underwent coronary angiography between January 2006 and December 2012 were evaluated retrospectively. A total of 146 patients with SCF were compared with 148 patients with normal coronary arteries according to demographic data, complete blood count, and biochemical parameters.Results: The following parameters were significantly higher in SCF patients than in patients with normal coronary arteries: percentage of smokers (36.3% vs. 25%, p = 0.036), body mass index (26.69 +/- 2.84 vs. 26.07 +/- 3.15, p = 0.049), white blood cells (WBCs) (7.52 +/- 1.43 x 10(3) mm(-3) vs. 7.01 +/- 1.42 x 10(3) mm(-3), p = 0.002), red cell distribution width (RDW) (13.68 +/- 1.42% vs. 13.15 +/- 1.13%, p < 0.001), platelets (250.29 +/- 50.96 x 10(3) mm(-3) vs. 226.10 +/- 38.02 x 10(3) mm(-3), p < 0.001), plateletcrit (PCT) (0.214 +/- 0.40% vs. 0.184 +/- 0.29%, p < 0.001), mean platelet volume (8.63 +/- 1.10 fL vs. 8.22 +/- 0.83 fL, p < 0.001), platelet distribution width (PDW) (16.58 +/- 0.76% vs. 16.45 +/- 0.57%, p = 0.028), and neutrophils (4.44 +/- 1.25 x 10(3) mm(-3) vs. 4.12 +/- 1.24 x 10(3) mm(-3), p = 0.029). Positive PCT values [odds ratio (OR), 4.165; 95% confidence interval (CI), 2.493-6.959; p < 0.001) and RDW (OR, 1.304; 95% Cl, 1.034-1.645; p = 0.025) were independent predictors of SCF.Conclusion: Although within the normal range, the increased numbers of WBCs and neutrophils in patients with SCF suggest that SCF may be a subclinical inflammatory condition. Furthermore, increased RDW and PDW in SCF patients may cause microvascular blood flow resistance due to impaired cell deformability. The PCT provides reliable data regarding total platelet mass and may be a useful predictor of SCF. (C) 2013 Japanese College of Cardiology. Published by Elsevier Ltd. All rights reserved.