Functional anatomy of the human thalamus at rest
Functional anatomy of the human thalamus at rest
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DOI：
10.1016/j.neuroimage.2016.12.071
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发表时间：
2017-02-15
期刊：
影响因子：
5.7
通讯作者：
Grodd, Wolfgang
中科院分区：
文献类型：
--
作者：
Kumar, Vinod Jangir;van Oort, Erik;Grodd, Wolfgang
在目前的工作中，我们使用静息状态功能磁共振成像研究丘脑在休息时的功能解剖，通过应用独立成分分析来描绘丘脑的子结构成稳定和可重复的包裹左右丘脑。我们确定了15个功能不同的丘脑包裹，不同的偏侧性和大小，但表现出对应的18 cytoarchitectonally定义的核。我们在确定基于DWI的皮质纤维通路中表征了它们的结构连接性，并发现了到不同皮质区域的选定投影。相反，这些包裹的功能连接并不局限于某些皮质区域或叶。最后，我们评估了皮质的预测，并发现特定的皮质下和皮质模式的每个包裹，其中部分表现出对应的丘脑-皮质连接图的小鼠。
In the present work, we used resting state-fMRI to investigate the functional anatomy of the thalamus at rest by applying an Independent Component Analysis to delineate thalamic substructures into stable and reproducible parcels for the left and right thalamus. We determined 15 functionally distinct thalamic parcels, which differed in laterality and size but exhibited a correspondence with 18 cytoarchitectonally defined nuclei. We characterized their structural connectivity in determining DWI based cortical fiber pathways and found selected projections to different cortical areas. In contrast, the functional connections of these parcels were not confined to certain cortical areas or lobes. We, finally evaluated cortical projections and found particular subcortical and cortical pattern for each parcel, which partly exhibited a correspondence with the thalamo-cortical connectivity maps of the mouse.