Early life programming of abdominal adiposity in adolescents: The HELENA Study.
Early life programming of abdominal adiposity in adolescents: The HELENA Study.
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DOI：
10.2337/dc09-0983
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发表时间：
2009-11
期刊：
影响因子：
16.2
通讯作者：
Healthy Lifestyle in Europe by Nutrition in Adolescence (HELENA) Study Group
中科院分区：
文献类型：
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作者：
Labayen I;Ruiz JR;Vicente-Rodríguez G;Turck D;Rodríguez G;Meirhaeghe A;Molnár D;Sjöström M;Castillo MJ;Gottrand F;Moreno LA;Healthy Lifestyle in Europe by Nutrition in Adolescence (HELENA) Study Group
目的探讨青少年出生体重与腹部肥胖症的关系。共有284名青少年(其中49.3%为女性)被纳入研究，年龄为14.9±1.2岁。出生体重和胎龄从父母记录中获得。采用双能X线骨密度仪测量腹型肥胖(R1、R2、R3三个区域)及躯干和全身脂肪质量。然后计算区域脂肪质量指数(FMI)，即脂肪质量除以身高的平方(躯干FMI和腹部FMI R1、R2和R3)。出生体重与腹部FMI r1、r2和r3呈负相关，与总脂肪质量、胎龄、性别、哺乳时间、青春期、体力活动和社会经济状况无关(均P<；0.01)。我们的研究表明，在青少年中，出生体重和腹部肥胖症之间呈负相关，与总脂肪量和其他潜在混杂因素无关。这些发现表明，胎儿营养，如出生体重所反映的，可能在以后的生活中对腹部肥胖症具有程序性影响。
To examine the relationship between birth weight and abdominal adiposity in adolescents. A total of 284 adolescents (49.3% of whom were female) aged 14.9 ± 1.2 years were included in the study. Birth weight and gestational age were obtained from parental records. Abdominal adiposity (in three regions: R1, R2, and R3) and trunk and total body fat mass were measured by dual-energy X-ray absorptiometry. Regional fat mass indexes (FMIs) were thereafter calculated as fat mass divided by the square of height (Trunk FMI and abdominal FMI R1, R2, and R3). Birth weight was negatively associated with abdominal FMI R1, R2, and R3 independently of total fat mass, gestational age, sex, breast-feeding duration, pubertal stage, physical activity, and socioeconomic status (all P < 0.01). Our study shows an inverse association between birth weight and abdominal adiposity in adolescents independently of total fat mass and other potential confounders. These findings suggest that fetal nutrition, as reflected by birth weight, may have a programming effect on abdominal adiposity later in life.