A blueprint for human whole-cell modeling.
A blueprint for human whole-cell modeling.
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DOI：
10.1016/j.coisb.2017.10.005
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发表时间：
2018-03
影响因子：
3.7
通讯作者：
Karr JR
中科院分区：
文献类型：
--
作者：
Szigeti B;Roth YD;Sekar JAP;Goldberg AP;Pochiraju SC;Karr JR
人类细胞的全细胞动力学模型是系统生物学的中心目标。这样的模型可以帮助研究人员了解细胞生物学，并帮助医生治疗疾病。尽管面临着巨大的挑战，我们相信人类全细胞模型正在迅速变得可行。为了制定实现人类全细胞模型的计划，我们分析了现有的单个细胞通路模型，调查了生物建模群落，并反思了我们开发细菌全细胞模型的经验。在这些分析的基础上，我们提出了一个项目的计划，称为人类全细胞建模项目，以实现人类全细胞模型。该计划的基础包括技术开发、标准开发和跨学科合作。
Whole-cell dynamical models of human cells are a central goal of systems biology. Such models could help researchers understand cell biology and help physicians treat disease. Despite significant challenges, we believe that human whole-cell models are rapidly becoming feasible. To develop a plan for achieving human whole-cell models, we analyzed the existing models of individual cellular pathways, surveyed the biomodeling community, and reflected on our experience developing whole-cell models of bacteria. Based on these analyses, we propose a plan for a project, termed the Human Whole-Cell Modeling Project, to achieve human whole-cell models. The foundations of the plan include technology development, standards development, and interdisciplinary collaboration.