The effects of inhalation anaesthetics on common clinical pathology parameters in laboratory rats
The effects of inhalation anaesthetics on common clinical pathology parameters in laboratory rats
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DOI：
10.1016/j.fct.2007.03.005
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发表时间：
2007-09-01
影响因子：
4.3
通讯作者：
van Ravenzwaay, B.
中科院分区：
文献类型：
--
作者：
Deckardt, K.;Weber, I.;van Ravenzwaay, B.
研究了常用麻醉剂如乙醚、甲氧氟烷、异氟烷、二氧化碳（以100%、80%或60%与O2混合）对大鼠的毒性和临床病理学参数的影响。乙醚、甲氧氟烷和100% CO2在一些动物中诱导毒性。100% CO2、甲氧氟烷和异氟烷使雌性动物的红细胞、血红蛋白和红细胞压积降低。在雄性动物中，60% CO2、80% CO2、乙醚、异氟烷和甲氧氟烷使葡萄糖升高。异氟烷和所有CO2浓度均可降低雌性动物中的氯化物。异氟烷和甲氧氟烷可降低血清蛋白。钠、无机磷酸盐、钙和镁被甲氧氟烷和异氟烷降低，但被所有CO2浓度升高。用乙醚、甲氧氟烷或异氟烷还原钾。三碘甲状腺原氨酸和甲状腺素减少所有麻醉剂。催乳素被甲氧氟烷降低，但被乙醚和异氟烷升高。麻醉后，红细胞胆碱酯酶（E-ChE）活性显著降低（20-40%），所有CO2浓度在两种性别中均存在。E-ChE不受乙醚、甲氧氟烷或异氟烷的影响。血清和脑胆碱酯酶活性不受影响。E-ChE抑制与血液pH值降低相关，表明这是由酸中毒引起的。这是实际相关的风险评估胆碱酯酶抑制剂。结论：临床病理学数据的影响，所有麻醉剂。CO2/O-2（80%/20%）和异氟醚是最合适的麻醉药。如果要测定E-CbE活性，异氟烷是首选麻醉剂。(c)2007爱思唯尔有限公司保留所有权利。
Effects of common anaesthetics such as ether, methoxyflurane, isoflurane, carbon dioxide (at 100%, 80% or 60% admixed with 02) on toxicity and clinical pathology parameters in rats were investigated. Ether, methoxyflurane and 100% CO2 induced toxicity in some animals. Erythrocyte, haemoglobin and haematocrit were reduced in females by 100% CO2, methoxyflurane and isoflurane. Glucose was increased by 60% CO2, 80% CO2, ether, isoflurane and methoxyflurane in males. Chloride was reduced by isoflurane and all CO2 concentrations in females. Serum proteins were reduced by isoflurane and methoxyflurane. Sodium, inorganic phosphate, calcium and magnesium were reduced by methoxyflurane and isoflurane, but increased by all CO2 concentrations. Potassium was reduced by ether, methoxyflurane or isoflurane. Triiodothyronine and thyroxine were reduced by all anaesthetics. Prolactin was reduced by methoxyflurane, but raised by ether and isoflurane.Erythrocyte cholinesterase (E-ChE) activity is markedly reduced (20-40%) after anaesthesia, with all CO2 concentrations in both sexes. E-ChE was unaffected by ether, methoxyflurane, or isoflurane. Serum and brain cholinesterase activities were not affected. E-ChE inhibition correlated with decreased blood pH, suggesting that this was caused by acidosis. This is of practical relevance in the risk assessment of cholinesterase inhibitors.Conclusions: Clinical pathology data were affected by all anaesthetics. CO2/O-2 (80%/20%) and isoflurane are the most suitable anaesthetics. If E-CbE activity is to be determined, isoflurane is the anaesthetic of choice. (c) 2007 Elsevier Ltd. All rights reserved.