Inflammation and schizophrenia.
Inflammation and schizophrenia.
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DOI：
10.1586/14737175.7.7.789
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发表时间：
2007-07-01
影响因子：
4.3
通讯作者：
Henderson, David C
中科院分区：
文献类型：
--
作者：
Fan, Xiaoduo;Goff, Donald C;Henderson, David C
以前的研究表明，怀孕期间感染细菌或病毒的产前感染与成年后子女患精神分裂症的风险增加有关。此外，有证据表明产科并发症与精神分裂症有关。同时，还有一组单独的证据与亚临床慢性炎症和精神分裂症有关，这些人通常在成年后已经发展为精神分裂症。另一方面，在过去十年中出现了明确的实验、流行病学和临床证据，将炎症与胰岛素抵抗和代谢障碍的发展联系起来，这在精神分裂症人群中很常见。炎症可能是一种重要的常见病理生理过程，与精神分裂症的精神病理学和精神分裂症患者的代谢障碍有关。未来针对促炎细胞因子及其分子信号通路的研究可能会导致新的药物干预策略，治疗这种毁灭性精神疾病患者的精神病理学和医学共病。
Previous research has demonstrated that prenatal infections with bacterial or viral agents during pregnancy are associated with an increased risk of schizophrenia in the offspring during adulthood. Furthermore, there has been evidence linking obstetric complications to schizophrenia. In parallel, there is a separate body of evidence relating subclinical chronic inflammation and schizophrenia in individuals, usually in their adulthood, who have already developed schizophrenia. On the other hand, unequivocal experimental, epidemiological and clinical evidence has emerged during the past decade linking inflammation to the development of insulin resistance and metabolic disturbances, which are common in the schizophrenic population. Inflammation might be an important common pathophysiological process related to both schizophrenia psychopathology and metabolic disturbances seen in patients with schizophrenia. Future studies targeting proinflammatory cytokines and their molecular signaling pathways may lead to novel pharmacological intervention strategies treating both psychopathology and medical comorbidity in patients with this devastating mental illness.