The Effect of Bowman-Birk Inhibitor from Soybeans on the Sensitivity of Prostate Cancer Stem-like Cells to Anti-androgen Agent
The Effect of Bowman-Birk Inhibitor from Soybeans on the Sensitivity of Prostate Cancer Stem-like Cells to Anti-androgen Agent
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DOI：
10.3136/fstr.26.553
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发表时间：
2020-01-01
影响因子：
0.6
通讯作者：
Yano, Tomohiro
中科院分区：
文献类型：
--
作者：
Endo, Daiki;Kaneko, Saki;Yano, Tomohiro
前列腺干细胞样细胞对抗雄激素药物表现出耐药性，并有助于这种癌症的复发。因此，克服前列腺癌干细胞样细胞耐药性的新方法至关重要。本研究调查大豆衍生的Bowman-Birk抑制剂（BBI）是否可以消除来自雄激素依赖性前列腺癌细胞系（LNCaP细胞）的前列腺癌干细胞样细胞对抗雄激素剂的抗性。LNCaP干细胞样细胞表现出更强的抵抗雄激素拮抗剂，氟替卡松，比LNCaP亲本细胞。LNCaP干细胞样细胞暴露于BBI处理降低了它们的干性和对荧光素的抗性。与此同时，LNCaP干细胞样细胞显示出基于典型雄激素控制基因前列腺特异性抗原变化的阳性反应。这些结果表明，BBI作为候选药物的潜力，以减少前列腺癌干细胞样细胞对抗雄激素药物的耐药性。
Prostate stem-like cells exhibit resistance to anti-androgen agents and contribute to the recurrence of this cancer. A novel approach to overcome the resistance of prostate cancer stem-like cells is thus essential. The present study investigated whether soybean derived Bowman-Birk inhibitor (BBI) could abrogate the resistance of prostate cancer stem-like cells from an androgen-dependent prostate cancer cell line (LNCaP cells) to an anti-androgen agent. The LNCaP stem-like cells exhibited stronger resistance to an androgen antagonist, flutamide, than LNCaP parental cells. Exposure of LNCaP stem-like cells to BBI treatment reduced their stemness and resistance to flutamide. In parallel, LNCaP stem-like cells showed a positive response based on changes in the typical androgen-governed gene, prostate-specific antigen. These results suggest the potential of BBI as a candidate to reduce the resistance of prostate cancer stem-like cells to antiandrogen agents.