F-BAR family proteins, emerging regulators for cell membrane dynamic changes-from structure to human diseases.
F-BAR family proteins, emerging regulators for cell membrane dynamic changes-from structure to human diseases.
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F-BAR 家族蛋白是细胞膜动态变化（从结构到人类疾病）的新兴调节因子。
DOI：
10.1186/s13045-015-0144-2
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发表时间：
2015-05-09
影响因子：
28.5
通讯作者：
Wang H
中科院分区：
文献类型：
--
作者：
Liu S;Xiong X;Zhao X;Yang X;Wang H
真核细胞膜在生理和病理过程中发生曲率的动态变化。在过去的十年中，一个新的蛋白质家族，Fes/CIP 4同源Bin/Amphiphysin/Rvs（F-BAR）结构域蛋白，已被确定为膜曲率调节中最重要的协调蛋白。F-BAR结构域家族是与细胞膜动态变化相关的Bin/Amphiphysin/Rvs（BAR）结构域超家族的成员。然而，F-BAR蛋白在膜结构调控中的分子基础和生物学功能尚不清楚。F-BAR蛋白的病理生理作用尚不清楚。本文综述了BAR结构域超家族的结构和功能，根据结构域将F-BAR家族蛋白分为9个亚家族，并对F-BAR蛋白的结构、结构域相互作用和功能相关性进行了分析。一般来说，F-BAR蛋白通过F-BAR结构域与膜磷脂结合而与细胞膜结合，并通过Src同源性-3（SH 3）结构域与其伴侣蛋白的相互作用而引发膜弯曲和断裂。这一过程引起膜的动态变化，并导致七个重要的细胞生物学功能，其中包括内吞作用，吞噬作用，丝状伪足，片状伪足，胞质分裂，粘附，和podosome的形成，通过不同的信号转导途径确定的特定结构域结合伙伴。这些细胞功能在许多生理和病理生理过程中起着重要作用。我们进一步总结了在各种疾病和发育障碍中观察到的F-BAR蛋白表达和突变变化。结合F-BAR蛋白的结构特点和功能意义，我们推测F-BAR蛋白可能通过转运细胞外物质、调节细胞运输和运动、提呈抗原、介导细胞外基质降解、传递细胞增殖信号等途径参与生理和病理生理过程。
Eukaryotic cell membrane dynamics change in curvature during physiological and pathological processes. In the past ten years, a novel protein family, Fes/CIP4 homology-Bin/Amphiphysin/Rvs (F-BAR) domain proteins, has been identified to be the most important coordinators in membrane curvature regulation. The F-BAR domain family is a member of the Bin/Amphiphysin/Rvs (BAR) domain superfamily that is associated with dynamic changes in cell membrane. However, the molecular basis in membrane structure regulation and the biological functions of F-BAR protein are unclear. The pathophysiological role of F-BAR protein is unknown. This review summarizes the current understanding of structure and function in the BAR domain superfamily, classifies F-BAR family proteins into nine subfamilies based on domain structure, and characterizes F-BAR protein structure, domain interaction, and functional relevance. In general, F-BAR protein binds to cell membrane via F-BAR domain association with membrane phospholipids and initiates membrane curvature and scission via Src homology-3 (SH3) domain interaction with its partner proteins. This process causes membrane dynamic changes and leads to seven important cellular biological functions, which include endocytosis, phagocytosis, filopodium, lamellipodium, cytokinesis, adhesion, and podosome formation, via distinct signaling pathways determined by specific domain-binding partners. These cellular functions play important roles in many physiological and pathophysiological processes. We further summarize F-BAR protein expression and mutation changes observed in various diseases and developmental disorders. Considering the structure feature and functional implication of F-BAR proteins, we anticipate that F-BAR proteins modulate physiological and pathophysiological processes via transferring extracellular materials, regulating cell trafficking and mobility, presenting antigens, mediating extracellular matrix degradation, and transmitting signaling for cell proliferation.
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影响因子：
64.5
作者：
Charrier C;Joshi K;Coutinho-Budd J;Kim JE;Lambert N;de Marchena J;Jin WL;Vanderhaeghen P;Ghosh A;Sassa T;Polleux F
通讯作者：
Polleux F
影响因子：
4.8
作者：
Bu, Wenyu;Chou, Ai Mei;Ahmed, Sohail
通讯作者：
Ahmed, Sohail
影响因子：
9.2
作者：
Bai S;Zeng R;Zhou Q;Liao W;Zhang Y;Xu C;Han M;Pei G;Liu L;Liu X;Yao Y;Xu G
通讯作者：
Xu G
影响因子：
3.7
作者：
Edeling MA;Sanker S;Shima T;Umasankar PK;Höning S;Kim HY;Davidson LA;Watkins SC;Tsang M;Owen DJ;Traub LM
通讯作者：
Traub LM
DOI：
10.1073/pnas.121433898
发表时间：
2001-07-17
影响因子：
11.1
作者：
Fuchs, U;Rehkamp, G;Borkhardt, A
通讯作者：
Borkhardt, A