Lewis Acid Directed Regioselective Metalations of Pyridazine
Lewis Acid Directed Regioselective Metalations of Pyridazine
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DOI：
10.1002/anie.201903839
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发表时间：
2019-07-01
影响因子：
16.6
通讯作者：
Knochel, Paul
中科院分区：
文献类型：
--
作者：
Balkenhohl, Moritz;Jangra, Harish;Knochel, Paul
单齿或双齿硼刘易斯酸在位置C3（邻位产物）或C4 Meta产物中引发哒嗪的区域选择性镁化或锌化。借助哒嗪和哒嗪/刘易斯酸配合物的pK（a）值，对金属化反应的区域选择性进行了合理化。
Mono- or bidentate boron Lewis acids trigger a regioselective magnesiation or zincation of pyridazine in position C3 (ortho product) or C4 meta product). The regioselectivity of the metalation was rationalized with the help of calculated pK(a) values of both pyridazine and pyridazine/Lewis acid complexes.