Hypocalcemia following thyroid surgery: incidence and risk factors. A longitudinal multicenter study comprising 2,631 patients
Hypocalcemia following thyroid surgery: incidence and risk factors. A longitudinal multicenter study comprising 2,631 patients
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DOI：
10.1007/s12020-014-0209-y
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发表时间：
2014-11-01
期刊：
影响因子：
3.7
通讯作者：
De Palma, Maurizio
中科院分区：
文献类型：
--
作者：
Puzziello, Alessandro;Rosato, Lodovico;De Palma, Maurizio
术后低钙血症是甲状腺全切除术最常见的并发症。它可能有延迟发作，因此延迟出院，需要钙替代治疗来缓解临床症状。在7个月的时间里，对2,631例连续接受原发性或完全甲状腺切除术的患者进行前瞻性随访，并对术后甲状旁腺功能减退进行分析。数据通过问卷调查从隶属于意大利内分泌外科协会（Club delle Unita di EndocrinoChirurgia-UEC）的39家意大利内分泌外科单位进行前瞻性收集，甲状腺手术是这些单位的常规手术。甲状旁腺功能减退的发生率为28.8%（757例），包括短暂性低钙血症（27.9% -734例）和永久性低钙血症（0.9% -23例）。无症状低钙血症发生率为70.80%。永久性低钙血症的发生率在有症状的低钙血症组（7.5%）高于无症状的低钙血症组（1.5%）。女性患者术后出现短暂性低钙血症的频率高于男性患者(分别为29.7%和21.2%
Postoperative hypocalcemia is the most frequent complication of total thyroidectomy. It may have a delayed onset, and therefore delays the discharge from the hospital, requiring calcium replacement therapy to alleviate clinical symptoms. During a 7-month period, 2,631 consecutive patients undergoing primary or completion thyroidectomy were prospectively followed up and underwent analysis regarding postoperative hypoparathyroidism. Data were prospectively collected by questionnaires from 39 Italian endocrine surgery units affiliated to the Italian Endocrine Surgery Units Association (Club delle Unita di EndocrinoChirurgia-UEC), where thyroid surgery is routinely performed. The incidence of hypoparathyroidism was 28.8 % (757 patients), including transient hypocalcemia (27.9 %-734 patients) and permanent hypocalcemia (0.9 %-23 patients). The rate of asymptomatic hypocalcemia was 70.80 %. The incidence of permanent hypocalcemia was higher in the symptomatic hypocalcemia group (7.5 %) than in asymptomatic one (1.5 %). Female patients experienced a transient postoperative hypocalcemia more frequently than male patients (29.7 and 21.2 %, respectively; p