Cutting Edge: Expression of XCR1 Defines Mouse Lymphoid-Tissue Resident and Migratory Dendritic Cells of the CD8α+ Type
Cutting Edge: Expression of XCR1 Defines Mouse Lymphoid-Tissue Resident and Migratory Dendritic Cells of the CD8α+ Type
复制标题
DOI：
10.4049/jimmunol.1101717
复制
发表时间：
2011-11-01
影响因子：
4.4
通讯作者：
Dalod, Marc
中科院分区：
文献类型：
--
作者：
Crozat, Karine;Tamoutounour, Samira;Dalod, Marc
树突状细胞 (DC) 的亚群已根据其功能和解剖位置进行了描述。传统的 DC 亚群是通过淋巴组织 (LT) 中 CD11b 和 CD8 α 的相互表达以及非 LT (NLT) 中 CD11b 和 CD103 的相互表达来定义的。脾脏 CD8 α(+) 和真皮 CD103(+) DC 具有较高的 Ag 交叉呈递效率以及对特定转录因子的发育依赖性。然而，目前尚不清楚所有 NLT 衍生的 CD103(+) DC 和 LT 驻留 CD8 α(+) DC 是否相似，尽管它们的解剖位置不同。 XCR1 先前被描述为仅在小鼠脾脏 CD8 α(+) DC 和人血 BDCA3(+) DC 上表达。在本文中，我们证明了LT驻留CD8α(+) DC和NLT衍生的CD103(+) DC特异性表达XCR1，并且具有独特的转录指纹特征，无论其组织来源如何。因此，CD8 α(+) DC 和 CD103(+) DC 属于常见的 DC 子集，可通过全身 XCR1 表达明确识别。免疫学杂志，2011，187：4411-4415。
Subsets of dendritic cells (DCs) have been described according to their functions and anatomical locations. Conventional DC subsets are defined by reciprocal expression of CD11b and CD8 alpha in lymphoid tissues (LT), and of CD11b and CD103 in non-LT (NLT). Spleen CD8 alpha(+) and dermal CD103(+) DCs share a high efficiency for Ag cross-presentation and a developmental dependency on specific transcription factors. However, it is not known whether all NLT-derived CD103(+) DCs and LT-resident CD8 alpha(+) DCs are similar despite their different anatomical locations. XCR1 was previously described as exclusively expressed on mouse spleen CD8 alpha(+) DCs and human blood BDCA3(+) DCs. In this article, we showed that LT-resident CD8 alpha(+) DCs and NLT-derived CD103(+) DCs specifically express XCR1 and are characterized by a unique transcriptional fingerprint, irrespective of their tissue of origin. Therefore, CD8 alpha(+) DCs and CD103(+) DCs belong to a common DC subset which is unequivocally identified by XCR1 expression throughout the body. The Journal of Immunology, 2011, 187: 4411-4415.