Human herpesvirus 6 encephalitis associated with hypersensitivity syndrome
Human herpesvirus 6 encephalitis associated with hypersensitivity syndrome
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DOI：
10.1002/ana.10194
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发表时间：
2002-06-01
影响因子：
11.2
通讯作者：
Yamada, T
中科院分区：
文献类型：
--
作者：
Fujino, Y;Nakajima, M;Yamada, T
超敏反应综合征是一种对数量有限的药物的严重全身反应，与人类疱疹病毒6的重新激活有关。56岁的男性患者在芳香抗惊厥药物引起的中毒性皮炎过程中出现急性边缘脑炎继发多器官衰竭。皮疹、高热、嗜酸性粒细胞增多、不典型淋巴细胞增多等临床特征与药物过敏综合征相一致。患者表现出人类疱疹病毒6型血清转换，聚合酶链式反应在脑脊液中检测到人类疱疹病毒6型DNA。据我们所知，这是第一例人类疱疹病毒6型脑炎与超敏综合征相关的报告。
Hypersensitivity syndrome, a serious systematic reaction to a limited number of drugs, is associated with the reactivation of human herpesvirus 6. A 56-year-old man developed acute limbic encephalitis followed by multiple organ failure during the course of toxic dermatitis induced by aromatic anticonvulsants. The clinical features of skin eruptions, high fever, eosinophilia, and atypical lymphocytosis were compatible with drug hypersensitivity syndrome. The patient showed seroconversion for human herpesvirus 6, and polymerase chain reaction detected human herpesvirus 6 DNA in the cerebrospinal fluid. To our knowledge, this is the first report of human herpesvirus 6 encephalitis associated with hypersensitivity syndrome.