Time- and Gender-Dependent Alterations in Mice during the Aging Process.
Time- and Gender-Dependent Alterations in Mice during the Aging Process.
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DOI：
10.3390/ijms241612790
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发表时间：
2023-08-14
影响因子：
5.6
通讯作者：
Li, Xiangning
中科院分区：
文献类型：
--
作者：
Jin, Jing;Yang, Xiaoquan;Gong, Hui;Li, Xiangning
与年轻人和成年人相比，老年人抵抗疾病或伤害的能力存在差异，其中一些明显的特征具有性别依赖性。然而，与年龄相关的内脏变化的性别差异尚不清楚。为了评估自然衰老过程中性别差异的潜在可能性，我们使用三个年龄组来研究对脾脏、肾脏和肾上腺的影响。免疫荧光结果显示，男性特异性p21蛋白集中在肾脏的肾小管上皮细胞中。组织学染色显示，随着年龄的增长，雄性小鼠肾脏肾囊下的皮质肾小管上皮细胞中的脂肪空泡频率增加。在雌性小鼠中，我们发现肾上腺皮质球状区的宽度随着年龄的增长而变化。相反，雄性的宽度有所减少。 ELISA分析显示，与女性相比，成人肾上腺组织中肾上腺素的含量较高，尤其是老年男性下降幅度更大。这些数据证实了雌性和雄性小鼠之间存在年龄依赖性差异。因此，在临床诊疗中，应将性别作为个体化治疗的主要因素之一。
Compared to young people and adults, there are differences in the ability of elderly people to resist diseases or injuries, with some noticeable features being gender-dependent. However, gender differences in age-related viscera alterations are not clear. To evaluate a potential possibility of gender differences during the natural aging process, we used three age groups to investigate the impact on spleens, kidneys, and adrenal glands. The immunofluorescence results showed that male-specific p21 proteins were concentrated in the renal tubule epithelial cells of the kidney. Histological staining revealed an increase in the frequencies of fat vacuoles located in the renal tubule epithelial cells of the cortex, under the renal capsule in the kidneys of male mice with age. In female mice, we found that the width of the globular zone in the adrenal gland cortex was unchanged with age. On the contrary, the male displayed a reduction in width. Compared to females, the content of epinephrine in adrenal gland tissue according to ELISA analysis was higher in adults, and a greater decline was observed in aged males particularly. These data confirmed the age-dependent differences between female and male mice; therefore, gender should be considered one of the major factors for personalized treatment in clinical diagnosis and treatment.
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影响因子：
--
作者：
Kumar, Surinder;Lombard, David B
通讯作者：
Lombard, David B
DOI：
10.1073/pnas.92.20.9363
发表时间：
1995-09-26
影响因子：
11.1
作者：
DIMRI, GP;LEE, XH;CAMPISI, J
通讯作者：
CAMPISI, J
影响因子：
37.8
作者：
Kunieda, Takeshige;Minamino, Tohru;Komuro, Issei
通讯作者：
Komuro, Issei
影响因子：
4.6
作者：
Park J;Miyakawa T;Shiokawa A;Nakajima-Adachi H;Tanokura M;Hachimura S
通讯作者：
Hachimura S
影响因子：
4.3
作者：
Papazova DA;Krebber MM;Oosterhuis NR;Gremmels H;van Zuilen AD;Joles JA;Verhaar MC
通讯作者：
Verhaar MC