Parkinson Disease and Dementia
Parkinson Disease and Dementia
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DOI：
10.1177/0891988716654985
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发表时间：
2016-09-01
影响因子：
2.6
通讯作者：
Kramberger, Milica G.
中科院分区：
文献类型：
--
作者：
Garcia-Ptacek, Sara;Kramberger, Milica G.
痴呆是帕金森病(PD)的常见并发症，每年约占帕金森病患者的10%。路易小体病理是帕金森病痴呆(PDD)发生的最重要因素，有证据表明与淀粉样蛋白有协同作用。PDD的临床表型超越了通常出现在早期帕金森病的执行困难综合征，并包括识别、记忆、注意力和视觉感知方面的缺陷。睡眠障碍、幻觉、抗精神病药物敏感性和波动经常出现。本文就PDD的流行病学、病理学、临床表现、治疗和预后等方面的最新知识进行综述。
Dementia is a frequent complication of Parkinson disease (PD) with a yearly incidence of around 10% of patients with PD. Lewy body pathology is the most important factor in the development of Parkinson disease dementia (PDD) and there is evidence for a synergistic effect with -amyloid. The clinical phenotype in PDD extends beyond the dysexecutive syndrome that is often present in early PD and encompasses deficits in recognition memory, attention, and visual perception. Sleep disturbances, hallucinations, neuroleptic sensitivity, and fluctuations are often present. This review provides an update on current knowledge of PDD including aspects of epidemiology, pathology, clinical presentation, management, and prognosis.