Associations of acoustically measured tongue/jaw movements and portion of time speaking with negative symptom severity in patients with schizophrenia in Italy and the United States
Associations of acoustically measured tongue/jaw movements and portion of time speaking with negative symptom severity in patients with schizophrenia in Italy and the United States
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DOI：
10.1016/j.psychres.2016.03.037
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发表时间：
2016-05-30
影响因子：
11.3
通讯作者：
Compton, Michael T.
中科院分区：
文献类型：
--
作者：
Bernardini, Francesco;Lunden, Anya;Compton, Michael T.
这是第一个跨语言的研究精神分裂症对语音的影响，通过分析语音参数与声音频谱测量。我们假设音高和共振峰的变异性降低与两个精神分裂症患者样本的阴性症状严重程度相关，一个来自意大利，一个来自美国。40名患者的自发语音录音。根据每个语音样本，创建F0（音高）和共振峰值（F1和F2，表示口腔的瞬时形状的共振带）以及录音中说话的部分（“浊音部分”，FV）的文件。语音指数和阴性症状严重程度的变异性之间的相关性进行了测试，并进一步研究使用回归分析。在意大利样本中观察到阴性症状评估量表（SANS）总分与F2标准差（SD）以及音高变异性（SD F0）之间存在有意义的负相关。我们还发现了有意义的协会SANS情感扁平化和SANS alogia与SD FO，和SANS avolition/冷漠和SD F2在意大利的样本。在这两个样本中，FV与SANS总分、无意志/冷漠和快感缺乏/不合群有意义地相关。(C)2016爱思唯尔爱尔兰有限公司版权所有。
This is the first cross-language study of the effect of schizophrenia on speech as measured by analyzing phonetic parameters with sound spectrography. We hypothesized that reduced variability in pitch and formants would be correlated with negative symptom severity in two samples of patients with schizophrenia, one from Italy, and one from the United States. Audio recordings of spontaneous speech were available from 40 patients. From each speech sample, a file of F0 (pitch) and formant values (F1 and F2, resonance bands indicating the moment-by-moment shape of the oral cavity), and the portion of the recording in which there was speaking ("fraction voiced," FV), was created. Correlations between variability in the phonetic indices and negative symptom severity were tested and further examined using regression analyses. Meaningful negative correlations between Scale for the Assessment of Negative Symptoms (SANS) total score and standard deviation (SD) of F2, as well as variability in pitch (SD F0) were observed in the Italian sample. We also found meaningful associations of SANS affective flattening and SANS alogia with SD FO, and of SANS avolition/apathy and SD F2 in the Italian sample. In both samples, FV was meaningfully correlated with SANS total score, avolition/apathy, and anhedonia/asociality. (C) 2016 Elsevier Ireland Ltd. All rights reserved.