Anti-apoptotic action of macrophage stimulating protein (MSP)
Anti-apoptotic action of macrophage stimulating protein (MSP)
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DOI：
10.1023/a:1011384609811
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发表时间：
2001-06-01
期刊：
影响因子：
7.2
通讯作者：
Leonard, EJ
中科院分区：
文献类型：
--
作者：
Danilkovitch-Miagkova, A;Leonard, EJ
MSP is a serum protein belonging to the plasminogen-related kringle domain protein family. In addition to macrophages, epithelial cells are also MSP targets. MSP is a multifunctional factor regulating cell adhesion and motility, growth and survival. MSP mediates its biological activities by activating a transmembrane receptor tyrosine kinase called RON in humans or SKT in mice. MSP can protect epithelial cells from apoptosis by activating two independent signals in the PI3-K/AKT or the MAPK pathway. The MAPK pathway mediates the MSP anti-apoptotic effect only if additional signaling pathways are activated through adhesion. This indicates that MSP receptors and integrins, the receptors mediating cell-matrix-dependent adhesion, can collaborate in promotion of cell survival. This adhesion-dependent pathway, which is essential for the MAPK-mediated anti-apoptotic effect, remains to be identified. A hypothesis that Stat3 might represent a key component of the adhesion-induced anti-apoptotic pathway is presented in this review.
