Diabetes Mellitus Increases the Risk of Bladder Cancer: An Updated Meta-Analysis of Observational Studies
Diabetes Mellitus Increases the Risk of Bladder Cancer: An Updated Meta-Analysis of Observational Studies
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DOI：
10.1089/dia.2013.0131
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发表时间：
2013-11-01
影响因子：
5.4
通讯作者：
Zhao, Yanping
中科院分区：
文献类型：
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作者：
Fang, Hong;Yao, Baodong;Zhao, Yanping
背景：越来越多的证据表明糖尿病（DM）可能与膀胱癌风险增加有关。我们进行了一项更新的荟萃分析，以检查糖尿病和膀胱癌风险之间的关系。材料与方法：我们系统地检索了EMBASE和Medline（PubMed）数据库（从开始到2013年2月1日），并审查了相关出版物的参考文献列表，以检索其他研究。使用随机效应模型计算相对风险（RR）和95%置信区间（CI）。结果：共有10项病例对照研究和14项队列研究符合纳入标准。对所有研究的分析表明，糖尿病与膀胱癌风险增加相关（RR 1.30，95%CI 1.18-1.43）。研究间存在异质性（P-异质性
Background: Increasing evidence suggests that diabetes mellitus (DM) may be associated with an increased risk of bladder cancer. We performed an updated meta-analysis to examine the association between DM and risk of bladder cancer. Materials and Methods: We systematically searched the EMBASE and Medline (PubMed) databases (from inception through February 1, 2013) and reviewed the reference lists of relevant publications to search for additional studies. Summary relative risks (RRs) with 95% confidence intervals (CIs) were calculated with random-effects models. Results: In total, 10 case-control and 14 cohort studies met the inclusion criteria. Analysis of all studies showed that DM was associated with an increased risk of bladder cancer (RR 1.30, 95% CI 1.18-1.43). There was heterogeneity among studies (P-heterogeneity