A Combined Magnetic-Acoustic Device for Simultaneous, Coaligned Application of Magnetic and Ultrasonic Fields
A Combined Magnetic-Acoustic Device for Simultaneous, Coaligned Application of Magnetic and Ultrasonic Fields
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DOI：
10.1002/admt.201800081
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发表时间：
2018-07-01
影响因子：
6.8
通讯作者：
Stride, Eleanor
中科院分区：
文献类型：
--
作者：
Barnsley, Lester C.;Gray, Michael D.;Stride, Eleanor
声响应微泡作为超声诊断和治疗应用的试剂已被广泛研究。人们对磁性功能化微泡作为多模态成像剂和靶向药物输送载体也产生了相当大的兴趣。在本文中，我们提出了一种集成设备的设计，该设备能够产生协同排列的磁场和声场，以便在特定位置积聚微气泡并以声学方式激活它们。对于这项概念验证研究，该设备被设计为将微泡集中在距离探针表面 10 毫米的地方，与临床前小动物模型中的相关组织深度相称。先前的研究表明，微泡浓度和空化活动持续时间与治疗效果呈正相关。该装置的实用性在含有单个血管（直径 1.2 毫米）的模拟组织模型中进行了体外测试。在 B 型超声成像下，在峰值流体速度为 4.2 mm 时观察到微泡积聚，并且相应的空化活动持续时间比在相同声场但没有磁铁的情况下所达到的时间长 4 倍以上。讨论了开发用于人类应用的更大规模设备的可行性。
Acoustically-responsive microbubbles have been widely researched as agents for both diagnostic and therapeutic applications of ultrasound. There has also been considerable interest in magnetically-functionalised microbubbles as multi-modality imaging agents and carriers for targeted drug delivery. In this paper, we present a design for an integrated device capable of generating co-aligned magnetic and acoustic fields in order to accumulate microbubbles at a specific location and to activate them acoustically. For this proof-ofconcept study, the device was designed to concentrate microbubbles at a distance of 10 mm from the probe's surface, commensurate with relevant tissue depths in preclinical small animal models. Previous studies have indicated that both microbubble concentration and duration of cavitation activity are positively correlated with therapeutic effect. The utility of the device was assessed in vitro tests in a tissue-mimicking phantom containing a single vessel (1.2 mm diameter). At a peak fluid velocity of 4.2 mm microbubble accumulation was observed under B-mode ultrasound imaging and the corresponding cavitation activity was sustained for a period more than 4 times longer than that achieved with an identical acoustic field but in the absence of a magnet. The feasibility of developing a larger scale device for human applications is discussed.