Cell adhesion molecules and actin cytoskeleton at immune synapses and kinapses
Cell adhesion molecules and actin cytoskeleton at immune synapses and kinapses
复制标题
DOI：
10.1016/j.ceb.2007.08.003
复制
发表时间：
2007-10-01
影响因子：
7.5
通讯作者：
Dustin, Michael L.
中科院分区：
文献类型：
--
作者：
Dustin, Michael L.
免疫突触是极化的免疫效应细胞和携带抗原的细胞之间稳定的粘连连接。免疫突触经常被观察到在接触平面上具有惊人的径向对称性，与突出的中央抗原受体簇被同心的黏附分子环和富含肌动蛋白的突起包围。免疫突触的放射区与迁移细胞使用的动态放线肌球蛋白模块有惊人的相似之处。破坏免疫突触的对称性会产生一个移动的粘连连接，可以被定义为Kinapse，它促进了免疫细胞在抗原提呈细胞表面移动时的信号整合。
The immunological synapse is a stable adhesive junction between a polarized immune effector cell and an antigen-bearing cell. Immunological synapses are often observed to have a striking radial symmetry in the plane of contact with a prominent central cluster of antigen receptors surrounded by concentric rings of adhesion molecules and actin-rich projections. There is a striking similarity between the radial zones of the immunological synapse and the dynamic actinomyosin modules employed by migrating cells. Breaking the symmetry of an immunological synapse generates a moving adhesive junction that can be defined as a kinapse, which facilitates signal integration by immune cells while moving over the surface of antigen-presenting cells.