White matter abnormalities in bipolar disorder and schizophrenia detected using diffusion tensor magnetic resonance imaging
White matter abnormalities in bipolar disorder and schizophrenia detected using diffusion tensor magnetic resonance imaging
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DOI：
10.1111/j.1399-5618.2008.00646.x
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发表时间：
2009-02-01
影响因子：
5.4
通讯作者：
McIntosh, Andrew M.
中科院分区：
文献类型：
--
作者：
Sussmann, Jessika E.;Lymer, G. Katherine S.;McIntosh, Andrew M.
在精神分裂症和双相情感障碍(BD)中都存在脑白质异常的强有力的定性和定量证据。弥散张量成像(DTI)研究提示这两种疾病的连接性改变。我们的目的是解决脑白质异常在这些疾病中的诊断特异性。DTI用于评估临床稳定的家族性BD(n=42)和家族性精神分裂症(n=28)患者以及对照组(n=38)的脑白质完整性。用基于体素的形态计量学和自动感兴趣区分析来测量分数各向异性(FA)的差异。与对照组相比，BD患者和精神分裂症患者在内囊前肢(ALIC)、丘脑前部放射(ATR)和钩状神经束区域的FA减少。患者组之间的直接比较发现，这些地区没有显著差异。没有一个发现与精神药物有关。精神分裂症和BD患者的大脑皮质、钩状束和ATR区域的完整性降低是常见的。这些结果意味着白质病理上的重叠，可能与这两种疾病的共同风险因素有关。
Strong qualitative and quantitative evidence exists of white matter abnormalities in both schizophrenia and bipolar disorder (BD). Diffusion tensor imaging (DTI) studies suggest altered connectivity in both disorders. We aim to address the diagnostic specificity of white matter abnormalities in these disorders.DTI was used to assess white matter integrity in clinically stable patients with familial BD (n = 42) and familial schizophrenia (n = 28), and in controls (n = 38). Differences in fractional anisotropy (FA) were measured using voxel-based morphometry and automated region of interest analysis.Reduced FA was found in the anterior limb of the internal capsule (ALIC), anterior thalamic radiation (ATR), and in the region of the uncinate fasciculus in patients with BD and those with schizophrenia compared with controls. A direct comparison between patient groups found no significant differences in these regions. None of the findings were associated with psychotropic medication.Reduced integrity of the ALIC, uncinate fasciculus, and ATR regions is common to both schizophrenia and BD. These results imply an overlap in white matter pathology, possibly relating to risk factors common to both disorders.