PHARMACOLOGY OF ANGIOTENSIN-II RECEPTORS IN THE KIDNEY
PHARMACOLOGY OF ANGIOTENSIN-II RECEPTORS IN THE KIDNEY
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DOI：
10.1038/ki.1994.426
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发表时间：
1994-12-01
影响因子：
19.6
通讯作者：
LEVENS, NR
中科院分区：
文献类型：
--
作者：
DEGASPARO, M;LEVENS, NR
肾脏血管紧张素II受体的药理学。在肾脏内，血管紧张素II(Ang-Il)对肾功能有很大的影响。Ang II的肾内作用包括调节肾血流、肾小球滤过率、肾小管上皮细胞转运、肾素释放和细胞生长。Ang II对肾脏的作用是通过特定的肾内受体介导的，根据其生理特性和对非肽和多肽类似物的选择性结合，可分为两个主要亚型，即AT(1)和AT(2)。受体存在于所有物种的肾脏中，主要位于肾小球、肾小管和肾血管系统，包括传入和传出小动脉。肾内AT(1)受体的调节基本上介导了Ang II所有已知的肾内效应。AT(1)受体，特别是AT(2)受体在胚胎肾脏大量表达，它们可能在发育和成熟中发挥作用。在一些物种中，肾内AT(2)受体在出生后不久就会消失。在成人肾脏存在AT(2)受体的物种中，它们在控制肾功能中的作用尚未明确。
Pharmacology of angiotensin II receptors in the kidney. Within the kidney angiotensin II (Ang Il) exerts potent effects on renal function. The intrarenal actions of Ang II include modulation of renal blood how, glomerular filtration rate, tubular epithelial transport, renin release and cellular growth. The actions of Ang II on the kidney are mediated by specific intrarenal receptors which, based upon physical characteristics and the selective binding of non-peptide and peptide analogs may be divided into two main subtypes, termed AT(1) and AT(2). AT, receptors are present within the kidneys of all species and are located predominantly in the glomerulus, the renal tubules and the renal vasculature, including the afferent and efferent arterioles. Modulation of AT(1) receptors within the kidney has been shown to mediate essentially all of the known intrarenal effects of Ang II. AT(1) receptors and particularly AT(2) receptors are expressed in large numbers in fetal kidney where they may play a role in development and maturation. In some species, intrarenal AT(2) receptors disappear shortly after birth. In those species where AT(2) receptors are present in the adult kidney their role in the control of renal function has not yet been clearly defined.