FGF-4 and titanium implants: a pilot study in rabbit bone.
FGF-4 and titanium implants: a pilot study in rabbit bone.
复制标题
FGF-4 和钛植入物：兔骨的初步研究。
DOI：
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发表时间：
2003
影响因子：
4.3
通讯作者：
S. Oida
中科院分区：
文献类型：
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作者：
V. Franke Stenport;C. Johansson;T. Sawase;Yasuharu Yamasaki;S. Oida
目的
评价局部单次注射氨基端截短的重组人成纤维细胞生长因子-4（rhFGF-4s）对钛植入物在兔骨中掺入的影响。
材料和方法
将36个螺纹钛植入物插入6只家兔的股骨和胫骨中。在植入物插入前三周，将10 μ g在变肽胶原载体中的FGF-4或单独的载体注射到预期的植入部位。6周后通过（i）共振频率分析和（ii）峰值移除扭矩测量进行生物力学评价。将种植体及其周围组织加工成不脱钙的研磨切片，然后对种植体螺纹区域和顶端部分的骨进行光镜定量。
结果
FGF-4处理的种植体显示，与相应的对照种植体相比，种植体顶端部分的骨面积显著增加。
结论
局部单次注射rhFGF-4可刺激骨中钛种植体周围的骨形成。然而，需要进一步的研究来证实这些结果，了解FGF的机制，并建立最佳剂量和递送方法。
AIM
To evaluate the effect of a local single injection of amino-terminally truncated recombinant human fibroblast growth factor-4 (rhFGF-4s) on titanium implant incorporation in a rabbit bone.
MATERIAL AND METHODS
Thirty-six threaded titanium implants were inserted into the femur and tibia of six rabbits. Three weeks prior to implant insertion 10 microg of FGF-4 in an altelocollagen carrier or the carrier alone was injected into the intended implant sites. Biomechanical evaluation by (i) resonance frequency analysis and (ii) peak removal torque measurements was performed after 6 weeks. The implants with surrounding tissue were processed to undecalcified ground sections followed by light-microscopic quantifications of the bone in threaded area and the apical parts of the implants.
RESULTS
A general trend, however not statistically significant, with higher mean values obtained in the above-mentioned tests was found. The FGF-4-treated implants revealed a significantly increased bone area in the apical part of the implants compared to the corresponding control implants.
CONCLUSION
A local single injection of rhFGF-4 may stimulate bone formation around titanium implants in bone. However, further research is required to confirm these results, understand the mechanisms of FGF, and establish optimal dose and delivery methods.