Effects of a diet rich in phytoestrogens on prostate-specific antigen and sex hormones in men diagnosed with prostate cancer
Effects of a diet rich in phytoestrogens on prostate-specific antigen and sex hormones in men diagnosed with prostate cancer
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DOI：
10.1016/j.urology.2004.04.009
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发表时间：
2004-09-01
期刊：
影响因子：
2.1
通讯作者：
Wahlqvist, ML
中科院分区：
文献类型：
--
作者：
Dalais, FS;Meliala, A;Wahlqvist, ML
目标。目的：探讨富含大豆和亚麻籽的饮食与对照饮食对前列腺癌患者前列腺癌生化指标的影响。29名诊断为前列腺癌并计划接受根治性前列腺切除术的男性被随机分为三组：大豆组（高植物雌激素）、大豆加亚麻籽组（高植物雌激素）或小麦组（低植物雌激素）。作为研究参与者日常饮食的一部分，一种面包是专门制作的，其中包含50克热处理（HT）大豆粉或50克高温大豆粉和20克亚麻籽。测量基线和术前前列腺特异性抗原（PSA）、游离PSA、睾酮、性激素结合球蛋白、游离雄激素指数和双氢睾酮水平。大豆粗粉组总PSA变化百分比（- 12.7% vs . 40%, P = 0.02）和游离/总PSA比值变化百分比（27.4% vs . - 15.6%, P = 0.01）与对照小麦组差异有统计学意义；在游离雄激素指数变化百分比（16.4% vs - 15.5%, P = 0.04）和游离/总PSA比值变化百分比（27.4% vs - 10%, P = 0.007）方面，HT大豆粉组与HT大豆粉加亚麻籽组比较差异显著。这项研究的数据表明，每天吃四片富含HT大豆粉的面包有利于前列腺癌患者的PSA水平和游离/总PSA比率。这项工作为流行病学研究提供了一些证据，这些研究声称，食用高植物雌激素饮食的男性人群患前列腺癌的风险降低。
Objectives. To determine the effects of diets rich in soy and linseed compared with a control diet on biochemical markers of prostate cancer in men diagnosed with prostate cancer.Methods. Twenty-nine men diagnosed with prostate cancer and scheduled to undergo a radical prostatectomy were randomized to one of three groups: soy (high phytoestrogen), soy and linseed (high phytoestrogen), or wheat (low phytoestrogen). A bread was specially manufactured to incorporate 50 g of heat-treated (HT) soy grits or 50 g of HT soy grits and 20 g of linseed as part of the study participant's daily diet. Baseline and preoperative levels of prostate-specific antigen (PSA), free PSA, testosterone, sex hormone-binding globulin, free androgen index, and dihydrotestosterone were measured.Results. Statistically significant differences were detected between the HT soy grits group and the control wheat group for the percentage of change in total PSA (- 12.7% versus 40%, P = 0.02) and the percentage of change in free/total PSA ratio (27.4% versus - 15.6%, P = 0.01); and between the HT soy grits group and the HT soy grits and linseed group for the percentage of change in free androgen index (16.4% versus - 15.5%, P = 0.04) and the percentage of change in free/total PSA ratio (27.4% versus - 10%, P = 0.007).Conclusions. The data from this study indicate that a daily diet containing four slices of a bread rich in HT soy grits favorably influences the PSA level and the free/total PSA ratio in patients with prostate cancer. This work provides some evidence to support epidemiologic studies claiming that male populations who consume high phytoestrogen diets have a reduced risk of prostate cancer development and progression.