Pulse-wave propagation in straight-geometry vessels for stiffness estimation: theory, simulations, phantoms and in vitro findings.
Pulse-wave propagation in straight-geometry vessels for stiffness estimation: theory, simulations, phantoms and in vitro findings.
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DOI：
10.1115/1.4007747
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发表时间：
2012-11
期刊：
影响因子：
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通讯作者：
D. Shahmirzadi;Ronny X. Li;E. Konofagou
中科院分区：
文献类型：
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作者：
D. Shahmirzadi;Ronny X. Li;E. Konofagou
脉搏波成像(PWI)是一种基于超声的、基于脉搏波传播的无创性表征动脉僵硬的方法。可靠的脉搏波在正常和病变动脉中传播的数值模型可以作为局部脉搏波分析的有力工具，并为体内PWI测量提供指导。本文的目的是(1)应用流体-结构相互作用(FSI)模拟直线形状的主动脉，以证实脉搏波速度(PWV)与管壁弹性系数之间的Moens-Korteweg关系，以及(2)针对体模和体外结果验证模拟结果。PWI在连续射频(RF)超声图像中描绘和跟踪脉搏波在体外犬主动脉腹壁的传播，并估计成像壁上的PWV。同样的系统也被用来对多个聚丙烯酰胺模型进行成像，模拟犬类的尺寸，并模拟更柔软和更坚硬的墙壁。最后，使用犬和体模研究中的模型参数对脉搏波传播进行三维双向耦合FSI模拟，并估计脉搏波的脉搏波传播速度。模拟结果与相应的Moens-Korteweg方程吻合较好。使用模拟和实验相结合的结果(R²=0.98)，在PWV？和E测量之间也建立了高度的线性相关性，证实了上述方程所建立的关系。
Pulse wave imaging (PWI) is an ultrasound-based method for noninvasive characterization of arterial stiffness based on pulse wave propagation. Reliable numerical models of pulse wave propagation in normal and pathological aortas could serve as powerful tools for local pulse wave analysis and a guideline for PWI measurements in vivo. The objectives of this paper are to (1) apply a fluid-structure interaction (FSI) simulation of a straight-geometry aorta to confirm the Moens-Korteweg relationship between the pulse wave velocity (PWV) and the wall modulus, and (2) validate the simulation findings against phantom and in vitro results. PWI depicted and tracked the pulse wave propagation along the abdominal wall of canine aorta in vitro in sequential Radio-Frequency (RF) ultrasound frames and estimates the PWV in the imaged wall. The same system was also used to image multiple polyacrylamide phantoms, mimicking the canine measurements as well as modeling softer and stiffer walls. Finally, the model parameters from the canine and phantom studies were used to perform 3D two-way coupled FSI simulations of pulse wave propagation and estimate the PWV. The simulation results were found to correlate well with the corresponding Moens-Korteweg equation. A high linear correlation was also established between PWV² and E measurements using the combined simulation and experimental findings (R² = 0.98) confirming the relationship established by the aforementioned equation.