Curcumin/Tween 20-incorporated cellulose nanoparticles with enhanced curcumin solubility for nano-drug delivery: characterization and in vitro evaluation
Curcumin/Tween 20-incorporated cellulose nanoparticles with enhanced curcumin solubility for nano-drug delivery: characterization and in vitro evaluation
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DOI：
10.1007/s10570-019-02445-6
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发表时间：
2019-06-01
期刊：
影响因子：
5.7
通讯作者：
Liou, Nai-Shang
中科院分区：
文献类型：
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作者：
Ching, Yern Chee;Gunathilake, Thennakoon Mudiyanselage S. U.;Liou, Nai-Shang
姜黄素是一种水溶性差的抗癌药物，通过将其溶解在常用的非离子表面活性剂介质中，将其装载到纤维素纳米晶体中。结果表明，纳米纤维素的载药量随着介质中表面活性剂浓度的增加而增加。纳米纤维素在表面活性剂介质中的载药量（7.73mg/g）显著高于在甲醇介质中的载药量（3.35mg/g）。纳米纤维素药物负载在表面活性剂介质（TW/CNC）显示出更高的药物释放相比，纳米纤维素药物负载在甲醇介质（METH/CNC）。模拟胃液中TW/CNC和METH/CNC的抑菌浓度分别为8.99mg/L和2.65mg/L。由于姜黄素在酸性介质中的稳定性增加，与磷酸盐缓冲盐水溶液相比，所有纳米粒在模拟胃液中显示出更高的药物释放。姜黄素在含4%（w/v）表面活性剂的蒸馏水中的最大溶出量为2.13mg/mL。紫外-可见光谱表明，姜黄素在体外释放后仍保持其化学活性。根据这些发现，认为将姜黄素掺入表面活性剂介质中的纳米纤维素中提供了将姜黄素递送至胃和上肠道的有前景的方法。[图形]。
A poorly water-soluble anticancer drug, curcumin was loaded into cellulose nanocrystals by dissolving it in a commonly used nonionic surfactant medium. Results showed that the drug loading capacity of nanocellulose increased with increasing the surfactant concentration of the medium. The drug loading capacity of nanocellulose in surfactant medium was significantly higher (7.73mg/g) when compared to the drug loading capacity (3.35mg/g) in methanolic medium. The nanocellulose drug loaded in surfactant medium (TW/CNC) showed higher drug release compared to the nanocellulose drug loaded in methanolic medium (METH/CNC). It was 8.99mg/L for TW/CNC and 2.65mg/L for METH/CNC in simulated gastric fluid. Due to the increased stability of curcumin in acidic medium, all the nanoparticles showed higher drug release in simulated gastric fluid compared to phosphate buffered saline solution. The maximum dissolution of curcumin was 2.13mg/mL in distilled water containing 4% (w/v) of surfactant. UV-visible spectra revealed that the curcumin retained its chemical activity after in vitro release. From these findings, it is believed that the incorporation of curcumin into nanocellulose in surfactant medium provides a promising approach for delivery of curcumin to stomach and upper intestinal tract.[GRAPHICS].