An unusual Fc receptor-related protein expressed in human centroblasts
An unusual Fc receptor-related protein expressed in human centroblasts
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DOI：
10.1073/pnas.022042699
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发表时间：
2002-03-19
影响因子：
11.1
通讯作者：
Colonna, M
中科院分区：
文献类型：
--
作者：
Facchetti, F;Cella, M;Colonna, M
在此，我们报告了在B细胞中表达的Fc受体同源物（FRE B）的鉴定，FRE是一种独特的B细胞特异性分子，与Fc γ RI（IgG Fc片段的受体I）有远亲关系，并在人染色体1q上的Fc γ R基因区内编码。FREE具有细胞内分布并且缺乏典型的跨膜结构域。此外，FREB缺乏真正的Fc片段结合区，并且不结合免疫球蛋白。通过使用特异性单克隆抗体，我们表明FREB优先在生发中心中心成中心细胞中表达，这些细胞经历亲和力成熟和类别转换重组。总之，这些特征表明，FREB可能在B细胞分化中具有独特的作用。FREE也在一些B细胞淋巴瘤中表达，其中大多数起源于中心母细胞。值得注意的是，FREE在弥漫性大B细胞淋巴瘤的亚群中表达，为这种B细胞恶性肿瘤的表征提供了独特的标志物。
Here, we report the identification of Fc receptor homolog expressed in B cells (FREB), a unique B cell-specific molecule that is distantly related to FcgammaRI (receptor I for the Fc fragment of IgG) and is encoded on human chromosome 1q, within the FcgammaR gene region. FREE has an intracellular distribution and lacks a canonical transmembrane domain. In addition, FREB lacks bona fide Fc fragment binding regions and does not bind immunoglobulins. By using specific monoclonal antibodies, we show that FREB is preferentially expressed in germinal center centroblasts, which undergo affinity maturation and class-switch recombination. Together, these characteristics indicate that FREB may have a unique role in B cell differentiation. FREE is also expressed in some B cell lymphomas, most of which have centroblast origin. Remarkably, FREE is expressed in a subset of diffuse large B cell lymphomas, providing a unique marker for the characterization of this B cell malignancy.