Cross-reactions of multifunctional methacrylates and acrylates
Cross-reactions of multifunctional methacrylates and acrylates
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DOI：
10.1080/000163501750541200
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发表时间：
2001-10-01
影响因子：
2
通讯作者：
Kanerva, L
中科院分区：
文献类型：
--
作者：
Kanerva, L
牙科丙烯酸单体（即丙烯酸酯和甲基丙烯酸酯）是重要的职业致敏剂。丙烯酸单体也可能在牙齿护理中引起过敏反应。不幸的是，丙烯酸类单体会发生交叉反应，即由一种丙烯酸类化合物引起的过敏性致敏作用会扩展到一种或多种其他丙烯酸类化合物。因此致敏个体通常是多过敏性的，因此不能暴露于任何化合物。在本审查方面的交叉反应性一般和数据从动物研究的多功能甲基丙烯酸酯和丙烯酸酯的交叉反应性进行了总结。牙科中使用了大量的丙烯酸单体，当患者或牙科人员变得敏感时，识别致敏个体可能接触的牙科丙烯酸制剂非常重要。已知致敏的牙科工作者由于牙科丙烯酸单体引起的职业性过敏性接触性皮炎或哮喘而停止在牙科工作。不幸的是，牙科中使用的丙烯酸单体的交叉反应性没有充分映射，以使敏感的人选择合适的化合物。另一个重要方面是牙科丙烯酸材料的产品声明应显示产品中存在的所有丙烯酸化合物-即使是浓度低于1%的丙烯酸单体/杂质。这可能有助于选择一种产品，敏感的个人可以使用。
Dental acrylic monomers (that is, acrylates and methacrylates) are important Occupational sensitizers. Acrylic monomers may also cause allergic reactions in dental care. Unfortunately, acrylic monomers crossreact-that is, allergic sensitization induced by one acrylic compound extends to one or more other acrylic compounds. therefore, sensitized individuals are often multiallergic and, accordingly, cannot be exposed to any of the compounds. In the present review aspects of cross-reactivity in general and data from animal studies of cross-reactivity of multifunctional methacrylates and acrylates are summarized. A multitude of acrylic monomers is used in dentistry, and when patients or dental personnel become sensitized, it is of great importance to identify the dental acrylic preparations to which the sensitized individual can be exposed. Sensitized dental workers are known to have ceased working in dentistry owing to occupational allergic contact dermatitis or asthma, caused by dental acrylic monomers. Unfortunately, cross-reactivity of acrylic monomers used in dentistry is not sufficiently mapped to enable selection of an appropriate compound for the sensitized person. Another important aspect is that product declarations of dental acrylic materials should show all acrylic compounds present in the products-even acrylic monomers/impurities with lower concentrations than 1%. This could help to select a product that the sensitized individual could use.