Enthesitis
Enthesitis
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DOI：
10.1016/j.berh.2006.03.007
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发表时间：
2006-06-01
影响因子：
5.2
通讯作者：
Olivieri, Ignazio
中科院分区：
文献类型：
--
作者：
D'Agostino, Maria Antonietta;Olivieri, Ignazio
附着点炎是脊柱关节炎的一个独特病理特征，可累及滑膜关节、软骨关节、韧带联合和关节外附着点。这篇综述的重点是外周关节外附着点炎，这是脊柱关节炎的临床标志。下肢的附着点比上肢的附着点更容易受累，其中以足跟附着点炎最为常见。附着点疼痛可能是轻度或中度，也可能是重度和致残性的。外周附着点炎可以在所有形式的脊柱关节炎中观察到，包括未分化的形式，并且可能是B27相关疾病过程的唯一长期临床表现。对脊柱关节炎的概念性理解和对骨骼炎症部位准确成像的能力，即超声和磁共振成像，证实了附着点炎是脊柱关节炎的原发性病变。由于抗肿瘤坏死因子-α药物的引入，这一进展与脊柱关节炎的治疗进展同时发生。
Enthesitis is a distinctive pathological feature of spondyloarthritis and may involve synovial joints, cartilaginous joints, syndesmoses and extra-articular entheses. This review focuses on peripheral extra-articular enthesitis, which is a clinical hallmark of spondyloarthritis. The entheses of the lower limbs are more frequently involved than those of the upper limbs, and heel enthesitis is the most frequent. Entheseal pain may be mild or moderate as well as severe and disabling. Peripheral enthesitis may be observed in all forms of spondyloarthritis, including the undifferentiated forms, and may, for a prolonged period, be the only longstanding clinical manifestation of the B27-associated disease process. The conceptual understanding of spondyloarthritis and the ability to image sites of skeletal inflammation accurately, i.e. ultrasound and magnetic resonance imaging, confirm that enthesitis is the primary lesion of spondyloarthritis. This advance has been occurring simultaneously with the therapeutic advances in spondyloarthritis due to the introduction of antitumour necrosis factor-alpha agents.