Inflammation-induced endothelial cell adhesion to lymphocytes, neutrophils, and monocytes. Role of homing receptors and other adhesion molecules.
Inflammation-induced endothelial cell adhesion to lymphocytes, neutrophils, and monocytes. Role of homing receptors and other adhesion molecules.
复制标题
炎症诱导的内皮细胞粘附至淋巴细胞、中性粒细胞和单核细胞。
DOI：
10.1097/00007890-198911000-00001
复制
发表时间：
1989
期刊：
影响因子：
6.2
通讯作者：
Butcher,EC
中科院分区：
文献类型：
--
作者：
Jutila,MA;Berg,EL;Kishimoto,TK;Picker,LJ;Bargatze,RF;Bishop,DK;Orosz,CG;Wu,NW;Butcher,EC
粘附于血管内皮是白细胞迁移到下层组织之前或必要的前奏。通过淋巴器官的组成性淋巴细胞运输由淋巴细胞表面上表达的分子（归巢受体）和淋巴组织内内皮细胞（HEV）上表达的配体（血管地址素）之间的组织特异性相互作用控制。初步证据表明，淋巴细胞可能采用相关的，但不同的相互作用，在他们进入一些慢性炎症部位。其他白细胞，如中性粒细胞和单核细胞，表达与淋巴细胞归巢受体相关或相同的分子，这些分子受到趋化因子的精细调节，似乎参与这些细胞归巢至炎症组织。此外，体内炎症诱导内皮细胞对白细胞的粘附增加，这无疑在调节白细胞外渗中起关键作用。组织和炎症特异性白细胞/内皮细胞粘附分子构成了抑制或操纵组织炎症早期阶段的有吸引力的靶标。
Adhesion to the vascular endothelium precedes or is a necessary prelude to leukocyte migration into the underlying tissue. Constitutive lymphocyte trafficking through lymphoid organs is controlled by tissue-specific interactions between molecules expressed on the surface of the lymphocyte (homing receptors) and ligands (vascular addressins) expressed on endothelial cells (HEV) within lymphoid tissues. Preliminary evidence suggests that lymphocytes may employ related but distinct interactions in their entry into some chronic sites of inflammation. Other leukocytes, such as neutrophils and monocytes, express molecules related or identical to lymphocyte homing receptors, and these molecules are exquisitely regulated by chemotactic factors and appear to be involved in the homing of these cells to inflamed tissues. In addition, inflammation in vivo induces increased endothelial cell adhesiveness for leukocytes that undoubtedly plays a key role in regulating leukocyte extravasation. Tissue-and inflammation-specific leukocyte/endothelial cell adhesion molecules constitute attractive targets for suppression or manipulation of the early stages of tissue inflammation.