Esterase-Activated Charge-Reversal Polymer for Fibroblast-Exempt Cancer Gene Therapy
Esterase-Activated Charge-Reversal Polymer for Fibroblast-Exempt Cancer Gene Therapy
复制标题
用于成纤维细胞豁免癌症基因治疗的酯酶激活电荷反转聚合物
DOI：
10.1002/adma.201603095
复制
发表时间：
2016-12-28
影响因子：
29.4
通讯作者：
Shen, Youqing
中科院分区：
文献类型：
--
作者：
Qiu, Nasha;Liu, Xiangrui;Shen, Youqing
通过细胞内信号触发的复合物的响应性解离在肿瘤中的选择性基因表达被证明。酯酶响应性电荷反转聚合物介导酯酶活性高的癌细胞中的选择性基因表达超过酯酶活性低的成纤维细胞。其使用TRAIL自杀基因的基因治疗有效地诱导HeLa细胞凋亡，但不会激活成纤维细胞分泌WNT16 B，从而实现了有效的癌症基因治疗，副作用少。
Selective gene expression in tumors via responsive dissociation of polyplexes triggered by intracellular signals is demonstrated. An esterase-responsive charge-reversal polymer mediates selective gene expression in the cancer cells high in esterases over fibroblasts low in esterase activity. Its gene therapy with the TRAIL suicide gene effectively induces apoptosis of HeLa cells but does not activate fibroblasts to secrete WNT16B, enabling potent cancer gene therapy with few side effects.