Mast cells in the pathogenesis of fibrosis.
Mast cells in the pathogenesis of fibrosis.
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DOI：
10.1007/s11926-003-0043-3
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发表时间：
2003-04-01
影响因子：
5
通讯作者：
Gruber, Barry L
中科院分区：
文献类型：
--
作者：
Gruber, Barry L
在硬皮病的早期阶段，真皮中存在一种“圆形细胞”炎性浸润物，这一点已经被认识到很长时间了。从这一基本观察中已经产生了相当多的研究，假设免疫细胞和成纤维细胞之间的相互作用在纤维化的发生中是最重要的。在最近的研究中，早期在受累组织中积聚的大量肥大细胞还没有得到很好的认识。这一更新的目的是展示肥大细胞如何与成纤维细胞相互作用，从而导致成纤维细胞激活和随后的细胞外纤维化。此外，肌成纤维细胞在硬化性疾病(如硬皮病)中代表关键的成纤维细胞表型的观点也得到了相当大的支持。组织肥大细胞与肌成纤维细胞表型的产生的关系一直是最近几个报道的焦点，也将被讨论。
It has been appreciated for quite some time that a "round cell" inflammatory infiltrate is present in the dermis during the early stages of scleroderma. Considerable research has emanated from this basic observation, with the assumption that interactions between immune cells and fibroblasts are paramount in the genesis of fibrosis. The large number of mast cells that accumulate early in involved tissues has been less appreciated in recent studies. The purpose of this update is to demonstrate how mast cells interact with fibroblasts in a manner that leads to fibroblast activation and subsequent extracellular fibrosis. Furthermore, the notion that myofibroblasts represent a critical fibroblast phenotype in sclerosing disorders, such as scleroderma, has also gained considerable support. The relationship of tissue mast cells to the generation of a myofibroblast phenotype has been the focus of several recent reports and will also be discussed.