Synthesis and characterization of injectable photocrosslinking poly (ethylene glycol) diacrylate based hydrogels
Synthesis and characterization of injectable photocrosslinking poly (ethylene glycol) diacrylate based hydrogels
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DOI：
10.1007/s00289-008-0932-8
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发表时间：
2008-07-01
期刊：
影响因子：
3.2
通讯作者：
Zhang, Shujiang
中科院分区：
文献类型：
--
作者：
Tan, Guoxin;Wang, Yingjun;Zhang, Shujiang
以聚乙二醇二丙烯酸酯（PEGDA）和甲基丙烯酸羟乙酯（HEMA）为前驱体，在氮气保护下，通过紫外光辐射制备了PEGDA基水凝胶。将PEGDA和HEMA前体分别以预定的进料比加入蒸馏水中。使用2-羟基-1-[4-（羟基乙氧基）苯基]-2-甲基-1-丙酮（Irgacure 2959）作为光引发剂。通过红外光谱、内部形貌、平衡溶胀比和动态接触角等对PEGDA基水凝胶进行了表征。结果表明：（1）PEGDA和HEMA的-C=C-键在光交联后消失，表明-C=C-键被消耗而形成水凝胶：（2）水凝胶的溶胀率受添加剂/前驱体比例和微孔网的影响较大;（3）随着PEGDA基水凝胶中HEMA含量的增加，平衡水含量（EWC）增加，接触角减小，这是由于聚合物和水之间的HEMA的强氢键相互作用。
The poly (ethylene glycol) diacrylate (PEGDA)-based hydrogels were prepared by UV radiation under nitrogen, using PEGDA and 2-hydroxyethyl methacrylate (HEMA) as precursors. The PEGDA and HEMA precursors were respectively added into distilled water at a predetermined feed ratio. 2-Hydroxy-1-[4-(hydroxyethoxy)phenyl]-2-methyl-1-propanone (Irgacure2959) was used as a photoinitiator. The PEGDA-based hydrogels were characterized by FT-IR spectra, interior morphology, equilibrium swelling ratio, and Dynamic contact angle (DCA). The results showed: (1) -C=C- bonds of PEGDA and HEMA disappeared after photocrosslinking, which indicated hydrogel formation by consuming -C=C- bonds; (2) swelling ratio of the hydrogels were greatly influenced by the additive precursor ratios and microporous net; (3) with HEMA content increasing in PEGDA-based hydrogels, equilibrium water content (EWC) increased and the contact angle decreased, which resulted from the strong H-bonding interactions of HEMA between the polymer and water.