Intra-articular injection of stromal vascular fraction for knee degenerative joint disease: a concise review of preclinical and clinical evidence
Intra-articular injection of stromal vascular fraction for knee degenerative joint disease: a concise review of preclinical and clinical evidence
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DOI：
10.1007/s11427-021-2090-3
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发表时间：
2022-05
期刊：
影响因子：
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通讯作者：
Yuan Liu;Liping Huang;Y. Zeng;Mingyang Li;Huiqi Xie;Bin Shen
中科院分区：
文献类型：
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作者：
Yuan Liu;Liping Huang;Y. Zeng;Mingyang Li;Huiqi Xie;Bin Shen
自体脂肪源性基质血管分数（SVF）是一种混合细胞群，已在再生整形手术中使用多年。在动物和临床研究方面，本文简要回顾了SVF治疗膝关节退行性关节病（膝关节退行性关节病，KDJD）的疗效，该疾病可引起疼痛、残疾，严重影响患者的生活。从数据库中检索和筛选了13项研究，包括6项动物研究和7项临床试验。临床研究荟荟性分析显示，关节内注射SVF联合辅助手术，可减轻KDJD患者的疼痛，改善Kellgren-Lawrence （KL）分级II-III级患者的早期功能恢复。
Autologous fat-derived stromal vascular fraction (SVF) is a mixed cell population that has been used for many years in regenerative plastic surgery. In terms of animal and clinical research, this concise review was performed to evaluate the efficacy of SVF in knee degenerative joint disease (KDJD), which could cause pain, disability and severely affect patients’ lives. Thirteen studies retrieved and screened from the databases were included, including six animal studies and seven clinical trials. The meta-analysis of clinical research shows that intra-articular injection of SVF, in combination with adjuvant surgery, could alleviate pain and improve early functional recovery for patients with KDJD at Kellgren-Lawrence (KL) grades II–III.