Relationship Between Visceral Adiposity and Bone Mineral Density in Korean Adults
Relationship Between Visceral Adiposity and Bone Mineral Density in Korean Adults
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DOI：
10.1007/s00223-010-9398-4
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发表时间：
2010-09-01
影响因子：
4.2
通讯作者：
Lim, Sung-Kil
中科院分区：
文献类型：
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作者：
Choi, Han Seok;Kim, Kwang Joon;Lim, Sung-Kil
本研究的目的是探讨CT测量的内脏和皮下脂肪与骨密度之间的关系，并确定与骨密度相关的代谢因素。我们研究了从延世大学医学院塞维兰斯医院的保健中心招募的461名受试者。采用多元回归分析来检验身体成分相关参数或代谢参数与骨密度之间的横断面关系。在调整体重和其他混杂因素后，内脏脂肪面积与男性(腰椎β=-0.133，P=0.049；股骨颈β=-0.135，P=0.037；全髋β=-0.179，P=0.005)和女性(腰椎β=-0.424，P=0.001；股骨颈β=-0.302，P=0.005；全髋β=-0.274，P=0.014)呈负相关。然而，在大多数部位，皮下脂肪面积与BMD之间没有统计学意义上的相关性。在代谢参数中，男性高密度脂蛋白胆固醇与骨密度呈正相关，而低密度脂蛋白与骨密度呈负相关。在女性中，总胆固醇和低密度脂蛋白与腰椎骨密度呈负相关。我们的结论是，在调整混杂因素后，内脏肥胖与BMD呈负相关，代谢因素可能在一定程度上导致了这种负相关。
The objective of the study was to investigate the relationship between visceral and subcutaneous adiposity measured by computed tomography and bone mineral density (BMD) and to identify the metabolic factors associated with BMD. We studied 461 subjects recruited from the health-care center at Severance Hospital, Yonsei University College of Medicine. Multivariate regression analyses were conducted to examine the cross-sectional associations between body composition-related or metabolic parameters and BMD. After adjusting for body weight and other confounders, visceral fat area had an inverse association with BMD in men (beta = -0.133, P = 0.049 for lumbar spine; beta = -0.135, P = 0.037 for femoral neck; beta = -0.179, P = 0.005 for total hip) and women (beta = -0.424, P < 0.001 for lumbar spine; beta = -0.302, P = 0.005 for femoral neck; beta = -0.274, P = 0.014 for total hip). However, the subcutaneous fat area showed no statistically significant relationship with BMD at most sites. Among the metabolic parameters, HDL cholesterol was positively associated with BMD, while LDL cholesterol was negatively associated with BMD in men. In women, total and LDL cholesterol were negatively associated with BMD at the lumbar spine. We conclude that visceral adiposity is inversely associated with BMD after adjusting for confounders and that metabolic factors may partly contribute to this inverse relation.