Circulating levels of inflammatory markers and cancer risk in the health aging and body composition cohort
Circulating levels of inflammatory markers and cancer risk in the health aging and body composition cohort
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DOI：
10.1158/1055-9965.epi-05-0316
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发表时间：
2005-10-01
影响因子：
3.8
通讯作者：
Kritchevsky, SB
中科院分区：
文献类型：
--
作者：
Il'yasova, D;Colbert, LH;Kritchevsky, SB
背景：慢性炎症与癌症的发生或进展有关。本研究检测了炎症标志物白细胞介素-6（IL-6）、C反应蛋白（CRP）和肿瘤坏死因子-α（TNF-α）的循环水平之间的关系。（TNF-α）和总的以及特定部位的癌症发病率。研究受试者（n = 2，438）为老年人（年龄70-79岁）参与健康衰老和身体成分研究，基线时未报告既往癌症诊断（非黑色素瘤皮肤癌除外）的受试者。在平均5.5年的随访期间确定了癌症事件（n = 296）。结果：IL-6、CRP和TNF-α在自然对数尺度上每增加1个单位，癌症发病率的校正风险比（95%置信区间）分别为1.13（0.94-1.37）、1.25（1.09-1.43）和1.28（0.96-1.70）。标志物与癌症死亡的相关性更强：IL-6的风险比为1.63（1.19-2.23），CRP为1.64（1.20-2.24），TNF-α为1.82（1.14-2.92）。尽管位点特异性分析的精确度较低，但我们的结果表明，所有三种标志物均与肺癌相关，IL-6和CRP与结直肠癌相关，CRP与乳腺癌相关。前列腺癌与任何这些markers.Conclusions：这些研究结果表明，（a）IL-6，CRP和TNF-α和癌症的风险之间的关联可能是特定的网站和（B）炎症标志物的水平增加与癌症死亡的风险比癌症发病率更强。
Background: Chronic inflammation is associated with processes that contribute to the onset or progression of cancer. This study examined the relationships between circulating levels of the inflammatory markers interleukin-6 (IL-6), Creactive protein (CRP), and tumor necrosis factor-alpha (TNF-alpha) and total as well as site-specific cancer incidence.Methods: Study subjects (n = 2,438) were older adults (ages 70-79 years) participating in the Health Aging and Body Composition study, who did not report a previous cancer diagnosis (except for nonmelanoma skin cancer) at baseline. Incident cancer events (n = 296) were ascertained during an average follow-up of 5.5 years. Inflammatory markers were measured in stored baseline fasting blood samples.Results: The adjusted hazard ratios (95% confidence intervals) for incident cancer associated with a 1-unit increase on the natural log-scale were 1.13 (0.94-1.37), 1.25 (1.09-1.43), and 1.28 (0.96-1.70) for IL-6, CRP, and TNF-a, respectively. Markers were more strongly associated with cancer death: hazard ratios were 1.63 (1.19-2.23) for IL-6, 1.64 (1.20-2.24) for CRP, and 1.82 (1.14-2.92) for TNF-alpha. Although precision was low for site-specific analyses, our results suggest that all three markers were associated with lung cancer, that IL-6 and CRP were associated with colorectal cancer, and that CRP was associated with breast cancer. Prostate cancer was not associated with any of these markers.Conclusions: These findings suggest that (a) the associations between IL-6, CRP, and TNF-a and the risk of cancer may be site specific and (b) increased levels of inflammatory markers are more strongly associated with the risk of cancer death than cancer incidence.